Evidence map›Paper›PMID 35246149›Full record

ArticleJournal of nanobiotechnology2022

Facile synthesis of near-infrared responsive on-demand oxygen releasing nanoplatform for precise MRI-guided theranostics of hypoxia-induced tumor chemoresistance and metastasis in triple negative breast cancer.

Dong Zhang, Yuanyuan You, Yuan Xu, Qingqing Cheng, Zeyu Xiao, Tianfeng Chen, Changzheng Shi, Liangping Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Dong Zhang *Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Yuanyuan You *Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Yuan XuDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Qingqing ChengDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Zeyu XiaoDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China.
Tianfeng ChenDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China. tchentf@jnu.edu.cn.ORCID http://orcid.org/0000-0001-6953-1342
Changzheng ShiDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China. tsczcn@jnu.edu.cn.
Liangping LuoDepartment of Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China. tluolp@jnu.edu.cn.
First Affiliated Hospital of Jinan University · CNJinan University · CNThe First People's Hospital of Shunde · CNZhuhai People's Hospital · CN

Funding

Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation 201905010003National Natural Science Foundation of China 81771973National Natural Science Foundation of China 81971672Postdoctoral Initial funding of the first affiliated hospital 809024Postdoctoral Science Foundation of China 2019M663366the Engineering Research Center of Medical Imaging Artificial Intelligence for Precision Diagnosis and Treatment of Guangdong Province, the Key Program of the Natural Science Foundation of Guangdong Province 2018B0303110011the Fundamental Research Funds for the Central Universities 21620101
6 · The paper itself

Abstract

backgroundHypoxia is an important factor that contributes to chemoresistance and metastasis in triple negative breast cancer (TNBC), and alleviating hypoxia microenvironment can enhance the anti-tumor efficacy and also inhibit tumor invasion.

methodsA near-infrared (NIR) responsive on-demand oxygen releasing nanoplatform (O

resultsThe near-infrared responsive on-demand oxygen releasing nanoplatform O

conclusionsOur work proposes a smart tactic guided by MRI and presents a valid approach for the reasonable design of NIR-responsive on-demand drug-releasing nanomedicine systems for precise theranostics in TNBC.

Indexed as

NanoparticlesPhotochemotherapyTriple Negative Breast NeoplasmsCell Line, TumorDrug Resistance, NeoplasmHumansHypoxiaMagnetic Resonance ImagingOxygenPrecision MedicineTissue DistributionTumor MicroenvironmentOxygenMRI-guided theranosticsNanoplatformOn-demand drug releaseTriple negative breast cancerTumor hypoxia

Identifiers

PMID35246149
PMCPMC8896283
OpenAlexW4221063520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.