Evidence map›Paper›PMID 35246147›Full record

ArticleMalaria journal2022

Oral susceptibility to ivermectin is over fifty times greater in a wild population of Anopheles albimanus mosquitoes from Belize than the STECLA laboratory reference strain of this mosquito.

Staci M Dreyer, Kelsey J Morin, Marla Magaña, Marie Pott, Donovan Leiva, Nicole L Achee, John P Grieco, Jefferson A Vaughan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Staci M DreyerUniversity of North Dakota, Grand Forks, ND, 58202, USA.
Kelsey J MorinUniversity of North Dakota, Grand Forks, ND, 58202, USA.
Marla MagañaBelize Vector and Ecology Center, Orange Walk Town, Belize.
Marie PottBelize Vector and Ecology Center, Orange Walk Town, Belize.
Donovan LeivaBelize Vector and Ecology Center, Orange Walk Town, Belize.
Nicole L AcheeBelize Vector and Ecology Center, Orange Walk Town, Belize.
John P GriecoBelize Vector and Ecology Center, Orange Walk Town, Belize.
Jefferson A VaughanUniversity of North Dakota, Grand Forks, ND, 58202, USA. jefferson.vaughan@und.edu.ORCID http://orcid.org/0000-0002-7067-0654
University of North Dakota · USUniversity of Notre Dame · US

Funding

Endectocide use in livestock as a tool to help eliminate malaria in Central AmericaR21AI119771 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI VAUGHAN, JEFFERSON ARCHER · 2017 to 2018
$382k
National Institute of Allergy and Infectious Diseases R21AI119771NIAID NIH HHS R21 AI119771
6 · The paper itself

Abstract

backgroundThe STECLA strain of Anopheles albimanus has been in continuous colony for many years and is the reference strain on which genomic studies for the species are based. Recently, the STECLA strain was demonstrated to be much less susceptible to ivermectin ingested in a blood meal (4-day LC

methodsTo investigate this, host-seeking An. albimanus were captured in northern Belize and used in membrane feeding bioassays of ivermectin, employing the same methods as described earlier with the STECLA strain.

resultsField-collected An. albimanus in Belize were 55 times more susceptible to ingested ivermectin than were the STECLA reference strain. Oral susceptibility to ivermectin in wild An. albimanus from Belize (4-day LC

conclusionsContrary to initial assessments using a highly inbred strain of mosquito, laboratory studies using a field population indicate that ivermectin treatment of livestock could reduce An. albimanus populations in areas of Central America and the Caribbean where malaria transmission may occur. Toxicity screening of ivermectin and other systemic parasiticides for malaria control should examine wild populations of the vector species being targeted.

Indexed as

AnophelesMalariaAnimalsBelizeHumansIvermectinLaboratoriesMosquito VectorsIvermectinAnopheles albimanusBelizeIvermectinSTECLA

Identifiers

PMID35246147
PMCPMC8896111
OpenAlexW4214833110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.