ArticleBMC cardiovascular disorders2022
Relationship between epicardial fat volume on cardiac CT and atherosclerosis severity in three-vessel coronary artery disease: a single-center cross-sectional study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Prognostic value of lesion-specific and proximal coronary segment pericoronary adipose tissue CT Attenuation in ischemic heart disease with angina pectoris.Scientific reports · 2025Article
- Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease.BMC cardiovascular disorders · 2025Article
- Evaluation of the Relationship between Presternal Fatty Tissue Thickness, Epicardial Fatty Tissue Volume, and Coronary Artery Disease.Current medical imaging · 2025Article
- CT angiography evaluation of epicardial fat volume and its association with coronary artery stenosis: A single-center cross-sectional study.Caspian journal of internal medicine · 2025Article
- Cohort profile: AI-driven national Platform for CCTA for clinicaL and industriaL applicatiOns (APOLLO).BMJ open · 2024Article
- Association of epicardial adipose tissue density with postoperative atrial fibrillation after isolated aortic valve replacement.International journal of cardiology. Heart & vasculature · 2024Article
- Relationship between quantitative epicardial adipose tissue based on coronary computed tomography angiography and coronary slow flow.BMC cardiovascular disorders · 2023Article
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11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ideal treatment strategy for stable three-vessel coronary artery disease (CAD) patients are difficult to determine and for patients undergoing conservative treatment, imaging evidence of coronary atherosclerotic severity progression remains limited. Epicardial fat volume (EFV) on coronary CT angiography (CCTA) has been considered to be associated with coronary atherosclerosis. Therefore, this study aims to evaluate the relationship between EFV level and coronary atherosclerosis severity in three-vessel CAD.
methodsThis retrospective study enrolled 252 consecutive patients with three-vessel CAD and 252 normal control group participants who underwent CCTA between January 2018 and December 2019. A semi-automatic method was developed for EFV quantification on CCTA images, standardized by body surface area. Coronary atherosclerosis severity was evaluated and scored by the number of coronary arteries with ≥ 50% stenosis on coronary angiography. Patients were subdivided into groups on the basis of lesion severity: mild (score = 3 vessels, n = 85), moderate (3.5 vessels ≤ score < 4 vessels, n = 82), and severe (4 vessels ≤ score ≤ 7 vessels, n = 85). The independent sample t-test, analysis of variance, and logistic regression analysis were used to evaluate the associations between EFV level and severity of coronary atherosclerosis.
resultsCompared with normal controls, three-vessel CAD patients had significantly higher EFV level (65 ± 22 mL/m
conclusionThree-vessel CAD patients do have higher EFV level than the normal controls. While, there may be an inverse relationship between EFV level and the severity of coronary atherosclerosis in patients with three-vessel CAD.
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