Evidence map›Paper›PMID 35246011›Full record

ArticleBioengineered2022

Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells.

Yong-Li Zhang, Moorim Kang, Jian-Cheng Wu, Meng-Yao Xie, Ruo-Yan Xue, Qi Tang, Hua Yang, Long-Cheng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yong-Li ZhangDepartment of Otolaryngology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Moorim KangRactigen Therapeutics, Nantong, Jiangsu, China.
Jian-Cheng WuRactigen Therapeutics, Nantong, Jiangsu, China.
Meng-Yao XieDepartment of Otolaryngology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Ruo-Yan XueDepartment of Otolaryngology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Qi TangDepartment of Otolaryngology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Hua YangDepartment of Otolaryngology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Long-Cheng LiRactigen Therapeutics, Nantong, Jiangsu, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The loss of inner ear hair cells leads to irreversible acoustic injury in mammals, and regeneration of inner ear hair cells to restore hearing loss is challenging.

Indexed as

Basic Helix-Loop-Helix ProteinsRNAAnimalsCell DifferentiationHairHair Cells, AuditoryHumansMammalsRegenerationATOH1 protein, humanBasic Helix-Loop-Helix ProteinsRNAATOH1hair cellhearing lossRNA activationSmall activating RNA

Identifiers

PMID35246011
PMCPMC8974106
OpenAlexW4221032412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.