Evidence map›Paper›PMID 35245784›Full record

ArticleVirology2022

The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases.

Kerstin Puchinger, Noemi Castelletti, Raquel Rubio-Acero, Christof Geldmacher, Tabea M Eser, Flora Deák, Ivana Paunovic, Abhishek Bakuli, Elmar Saathoff, Alexander von Meyer and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Kerstin PuchingerDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Noemi CastellettiDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, 85764, Neuherberg, Germany. Electronic address: castelletti@lrz.uni-muenchen.de.
Raquel Rubio-AceroDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Christof GeldmacherDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Tabea M EserDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Flora DeákDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Ivana PaunovicDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Abhishek BakuliDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Elmar SaathoffDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Alexander von MeyerInstitute for Laboratory Medicine, Medical Microbiology and Technical Hygienics, Munich Municipal Hospital Group, 81675, Munich, Germany.
Alisa MarkgrafDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Philine FalkDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Jakob ReichDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Friedrich RiessDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Philipp GirlGerman Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
Katharina MüllerGerman Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
Katja RadonCenter for International Health, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich (LMU), Ziemssenstr. 1, 80336, Munich, Germany.
Jessica Michelle Guggenbuehl NollerDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
Roman WölfelGerman Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
Michael HoelscherDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Inge KroidlDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Andreas WieserDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
Laura OlbrichDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany; Oxford Vaccine Group, Department of Paediatrics, And the NIHR Oxford Biomedical Research Centre, University of Oxford, OX1 2JD, Oxford, UK.
KoCo19 study group
LMU Klinikum · DEUniversität der Bundeswehr München · DELudwig-Maximilians-Universität München · DEHelmholtz Zentrum München · DEMünchen Klinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL: 3∙10

Indexed as

Viral LoadAdolescentAdultChildCohort StudiesCOVID-19Host-Pathogen InteractionsHumansLongitudinal StudiesMiddle AgedOutpatientsPandemicsSARS-CoV-2Serologic TestsSymptom AssessmentYoung AdultCOVID-19Immune responsePublic healthRT-PCRSARS-CoV-2Serological testingViral culture

Identifiers

PMID35245784
PMCPMC8855229
OpenAlexW4213281062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.