Evidence map›Paper›PMID 35245659›Full record

SynthesisInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022

Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis.

Mohammad Javad Nasiri, Moein Zangiabadian, Erfan Arabpour, Sirus Amini, Farima Khalili, Rosella Centis, Lia D'Ambrosio, Justin T Denholm, H Simon Schaaf, Martin van den Boom and 15 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 19 institutions in 15 countries.

Mohammad Javad NasiriDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mj.nasiri@hotmail.com.
Moein ZangiabadianDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: zangiabadian1998@gmail.com.
Erfan ArabpourDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: erfanarabpour1999@gmail.com.
Sirus AminiDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sirusamini@gmail.com.
Farima KhaliliDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: farimakhalili@yahoo.com.
Rosella CentisServizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: rosella.centis@icsmaugeri.it.
Lia D'AmbrosioPublic Health Consulting Group, Lugano, Switzerland. Electronic address: liadambrosio59@gmail.com.
Justin T DenholmVictorian Tuberculosis Program, Melbourne Health, Victoria, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia. Electronic address: justin.denholm@mh.org.au.
H Simon SchaafDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: hss@sun.ac.za.
Martin van den BoomWorld Health Organization Regional Office for the Eastern Mediterranean Region, Cairo, Egypt. Electronic address: vandenboomm@who.int.
Xhevat KurhasaniUBT Higher Education Institution, Prishtina, Kosovo. Electronic address: xhevat.kurhasani@gmail.com.
Margareth Pretti DalcolmoReference Center Hélio Fraga, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Electronic address: margarethdalcolmo@gmail.com.
Seif Al-AbriDirectorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman. Electronic address: salabri@gmail.com.
Jeremiah ChakayaDepartment of Medicine, dermatology and therapeutics, Kenyatta University, Nairobi, Kenya; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. Electronic address: chakaya.jm@gmail.com.
Jan-Willem AlffenaarSydney Institute of Infectious Diseases, University of Sydney, Sydney, NSW, Australia; School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; Westmead Hospital, Sydney, NSW, Australia. Electronic address: johannes.alffenaar@sydney.edu.au.
Onno AkkermanUniversity of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Tuberculosis center Beatrixoord, Haren, the Netherlands. Electronic address: o.w.akkerman@umcg.nl.
Denise Rossato SilvaFaculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Electronic address: denise.rossato@terra.com.br.
Marcela Muňoz-TorricoTuberculosis clinic, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico. Electronic address: dra_munoz@hotmail.com.
Barbara SeaworthDepartment of Medicine University of Texas Health Science Center, Tyler, Texas. Electronic address: Barbara.Seaworth@dshs.texas.gov.
Emanuele PontaliDepartment of Infectious Diseases, Galliera Hospital, Genoa, Italy. Electronic address: pontals@yahoo.com.
Laura SaderiUnità di Epidemiologia Clinica e Statistica Medica, Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italia. Electronic address: lsaderi@uniss.it.
Simon TiberiBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Electronic address: s.tiberi@qmul.ac.uk.
Alimuddin ZumlaDivision of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, United Kingdom; National Institute for Health Research Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address: a.zumla@ucl.ac.uk.
Giovanni Battista MiglioriServizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: giovannibattista.migliori@icsmaugeri.it.
Giovanni SotgiuUnità di Epidemiologia Clinica e Statistica Medica, Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italia. Electronic address: gsotgiu@uniss.it.
Shahid Beheshti University of Medical Sciences · IRIstituti Clinici Scientifici Maugeri · ITUniversity of Sassari · ITDalle Molle Institute for Artificial Intelligence Research · CHDesmond Tutu HIV Foundation · ZAEnte Ospedaliero Ospedali Galliera · ITFundação Oswaldo Cruz · BRInstituto Nacional de Enfermedades Respiratorias · MXKenyatta University · KEMinistry of Health · OMNational Institute for Health Research · GBQueen Mary University of London · GBThe University of Melbourne · AUThe University of Sydney · AUThe University of Texas Health Science Center at Tyler · USUniversidade Federal do Rio Grande do Sul · BRUniversity for Business and Technology · XKUniversity Medical Center Groningen · NLWorld Health Organization Regional Office for the Eastern Mediterranean · EG

Funding

World Health Organization 001
6 · The paper itself

Abstract

introductionMultidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is available to comprehensively evaluate the role of delamanid (DLM), we evaluated its effectiveness and safety.

methodsWe reviewed the relevant scientific literature published up to January 20, 2022. The pooled success treatment rate with 95% confidence intervals (CI) was assessed using a random-effect model. We assessed studies for quality and bias, and considered P<0.05 to be statistically significant.

resultsAfter reviewing 626 records, we identified 25 studies that met the inclusion criteria, 22 observational and 3 experimental, with 1276 and 411 patients, respectively. In observational studies the overall pooled treatment success rate of DLM-containing regimens was 80.9% (95% CI 72.6-87.2) with no evidence of publication bias (Begg's test; P >0.05). The overall pooled treatment success rate in DLM and bedaquiline-containing regimens was 75.2% (95% CI 68.1-81.1) with no evidence of publication bias (Begg's test; P >0.05). In experimental studies the pooled treatment success rate of DLM-containing regimens was 72.5 (95% CI 44.2-89.8, P <0.001, I

conclusionsIn MDR-TB patients receiving DLM, culture conversion and treatment success rates were high despite extensive resistance with limited adverse events.

Indexed as

NitroimidazolesTuberculosis, Multidrug-ResistantAntitubercular AgentsDiarylquinolinesHumansOxazolesTreatment OutcomeAntitubercular AgentsDiarylquinolinesNitroimidazolesOxazolesbedaquilinedelamanideffectivenessMDR-TBsafetyTB

Identifiers

PMID35245659
PMCPMC9731904
OpenAlexW4214812779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.