Evidence map›Paper›PMID 35245537›Full record

ReviewThe Journal of allergy and clinical immunology2022

Mechanisms and pathogenesis of chronic rhinosinusitis.

Atsushi Kato, Robert P Schleimer, Benjamin S Bleier

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 2 pooled it
47.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 2 syntheses or guidelines pooled it, 254 citations in OpenAlex.

  1. Pooled it
  2. Association between air pollution and allergic upper respiratory diseases: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Predictive value of blood eosinophil count and serum total immunoglobulin E for type 2 chronic rhinosinusitis according to allergic sensitization status.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Direct Maxillary Sinus Tissue Analysis forJournal of clinical medicine · 2026
    Article
  17. Article
  18. Multi-scale transcriptomic integration reveals epithelial state heterogeneity and remodeling-associated transcriptomic clusters in chronic rhinosinusitis with nasal polyps.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  19. Establishing the PMThe Journal of allergy and clinical immunology · 2026
    Article
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Atsushi KatoDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago. Electronic address: a-kato@northwestern.edu.
Robert P SchleimerDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago.
Benjamin S BleierDepartment of Otolaryngology-Head & Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston.
Northwestern University · USMassachusetts Eye and Ear Infirmary · US

Funding

Population-based CRS epidemiology: sex differences, natural history, and long-term outcomes based on clinically-defined phenotypes and biologically-based endotypes - GeisingerP01AI145818 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2019 to 2023
$9.3M
Initiators, biomarkers and mechanisms of epithelial dysfunction and immune pathogenesis in chronic rhinosinusitis and aspirin exacerbated respiratory disease (AERD)R01AI137174 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2018 to 2022
$3.1M
Direct CNS Delivery System for BDNF AntagoNATs using Heterotopic Mucosal Grafting for the Treatment of Parkinson's DiseaseR01NS108968 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI BLEIER, BENJAMIN · 2019 to 2023
$2.5M
NIAID NIH HHS P01 AI145818NIAID NIH HHS R01 AI137174NINDS NIH HHS R01 NS108968
6 · The paper itself

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and is historically divided into 2 main phenotypes: CRS with nasal polyps and CRS without nasal polyps. Inflammation in CRS is mainly characterized by 3 endotypes based on elevation of canonical lymphocyte cytokines: type (T) 1 (T1) by T

Indexed as

Nasal PolypsRhinitisSinusitisChronic DiseaseCytokinesHumansInflammationCytokinesChronic rhinosinusitisendotypeeosinophilsepithelial dysfunctionnasal polypsneutrophils

Identifiers

PMID35245537
PMCPMC9081253
OpenAlexW4214756872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.