Observational studyThe Annals of thoracic surgery2022
Fluid Accumulation After Neonatal Congenital Cardiac Operation: Clinical Implications and Outcomes.
Observational study in The Annals of thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Exploring Racial and Ethnic Disparities in Outcomes Following Pediatric Cardiac Surgery: A NEPHRON Study Analysis.Pediatric cardiology · 2026Article
- The incidence and risk factors associated with severe acute kidney injury and operative mortality in neonates following cardiac surgery: a single-center experience.Pediatric nephrology (Berlin, Germany) · 2026Article
- A Novel, Interpretable Machine Learning Model Predicts Furosemide Dosing After Congenital Cardiac Surgery.Pediatric cardiology · 2026Article
- Early Prediction of Postoperative Peritoneal Dialysis Using Lung Ultrasound Scoring in Neonates After Cardiopulmonary Bypass.Journal of cardiovascular development and disease · 2026Article
- Fluid restriction after pediatric cardiac surgery is independently associated With shorter mechanical ventilation: a retrospective cohort study With adjustment for cardiopulmonary bypass time.Frontiers in pediatrics · 2026Article
- Syndecan-1 as a Biomarker for Fluid Overload After High-Risk Pediatric Cardiac Surgery: A Pilot Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Observational
- Urine biomarkers, acute kidney injury, and fluid overload in neonatal cardiac surgery.Cardiology in the young · 2025Article
- Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative.Pediatric nephrology (Berlin, Germany) · 2024Article
- An update on the role of fluid overload in the prediction of outcome in acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Review
- Persistent acute kidney injury and fluid accumulation with outcomes after the Norwood procedure: report from NEPHRON.Pediatric nephrology (Berlin, Germany) · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Activation of renal epithelial NaFrontiers in pediatrics · 2024Article
- Early postoperative weight-based fluid overload is associated with worse outcomes after neonatal cardiac surgery.Pediatric nephrology (Berlin, Germany) · 2023Article
- Association of Urine Biomarkers With Acute Kidney Injury and Fluid Overload in Infants After Cardiac Surgery: A Single Center Ancillary Cohort of the Steroids to Reduce Systemic Inflammation After Infant Heart Surgery Trial.Critical care explorations · 2023Article
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundThis study was conducted to determine the association between fluid balance metrics and mortality and other postoperative outcomes after neonatal cardiac operation in a contemporary multicenter cohort.
methodsThis was an observational cohort study across 22 hospitals in neonates (≤30 days) undergoing cardiac operation. We explored overall percentage fluid overload, postoperative day 1 percentage fluid overload, peak percentage fluid overload, and time to first negative daily fluid balance. The primary outcome was in-hospital mortality. Secondary outcomes included postoperative duration of mechanical ventilation and intensive care unit (ICU) and hospital length of stay. Multivariable logistic or negative binomial regression was used to determine independent associations between fluid overload variables and each outcome.
resultsThe cohort included 2223 patients. In-hospital mortality was 3.9% (n = 87). Overall median peak percentage fluid overload was 4.9% (interquartile range, 0.4%-10.5%). Peak percentage fluid overload and postoperative day 1 percentage fluid overload were not associated with primary or secondary outcomes. Hospital resource utilization increased on each successive day of not achieving a first negative daily fluid balance and was characterized by longer duration of mechanical ventilation (incidence rate ratio, 1.11; 95% CI, 1.08-1.14), ICU length of stay (incidence rate ratio, 1.08; 95% CI, 1.03-1.12), and hospital length of stay (incidence rate ratio, 1.09; 95% CI, 1.05-1.13).
conclusionsTime to first negative daily fluid balance, but not percentage fluid overload, is associated with improved postoperative outcomes in neonates after cardiac operation. Specific treatments to achieve an early negative fluid balance may decrease postoperative care durations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.