ArticleCell2022
A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement.
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed.
- Article
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026Article
- Article
- Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study.MedComm · 2026Article
- Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Sensory-to-motor transformations: From serial pipelines to dynamic, distributed processes.Neuroscience and biobehavioral reviews · 2026Review
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- A Spatially Structured Spiking Network Model of Beta Traveling Waves and Their Attenuation in Motor Cortex.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Dynamic engagement of the motor cortex in controlling movement.bioRxiv : the preprint server for biology · 2026Article
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
56 more citing papers are in PubMed but not listed here.
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10 authors.
Funding
Abstract
Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity. Key questions are how these dynamic activity patterns are generated and how they relate to behavior. Here, we investigate the multi-regional neural circuits that link an auditory "Go cue" and the transition from planning to execution of directional licking. Ascending glutamatergic neurons in the midbrain reticular and pedunculopontine nuclei show short latency and phasic changes in spike rate that are selective for the Go cue. This signal is transmitted via the thalamus to the motor cortex, where it triggers a rapid reorganization of motor cortex state from planning-related activity to a motor command, which in turn drives appropriate movement. Our studies show how midbrain can control cortical dynamics via the thalamus for rapid and precise motor behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.