Evidence map›Paper›PMID 35245408›Full record

ArticleChembiochem : a European journal of chemical biology2022

Switchable DNA-Based Peroxidases Controlled by a Chaotropic Ion.

Tanner G Hoog, Matthew R Pawlak, Lauren M Aufdembrink, Benjamin R Bachan, Matthew B Galles, Nicholas B Bense, Katarzyna P Adamala, Aaron E Engelhart

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  5. Switchable DNA-Based Peroxidases Controlled by a Chaotropic Ion.Chembiochem : a European journal of chemical biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tanner G HoogDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.
Matthew R PawlakDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.
Lauren M AufdembrinkDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.
Benjamin R BachanDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.
Matthew B GallesStructural Acoustics Branch, NASA Langley Research Center, Mail Stop 463, Hampton, Virginia, 23681, USA.
Nicholas B BenseNASA Glenn Research Center, 21000 Brookpark Road, Cleveland, Ohio, 44135, USA.
Katarzyna P AdamalaDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.
Aaron E EngelhartDepartment of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota, 55455, USA.ORCID 0000-0002-1849-7700
University of Minnesota · USGlenn Research Center · USLangley Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we demonstrate a switchable DNA electron-transfer catalyst, enabled by selective destabilization of secondary structure by the denaturant, perchlorate. The system is comprised of two strands, one of which can be selectively switched between a G-quadruplex and duplex or single-stranded conformations. In the G-quadruplex state, it binds hemin, enabling peroxidase activity. This switching ability arises from our finding that perchlorate, a chaotropic Hofmeister ion, selectively destabilizes duplex over G-quadruplex DNA. By varying perchlorate concentration, we show that the DNA structure can be switched between states that do and do not catalyze electron-transfer catalysis. State switching can be achieved in three ways: thermally, by dilution, or by concentration.

Indexed as

G-QuadruplexesPeroxidasesDNAHeminPerchloratesDNAHeminPerchloratesPeroxidaseschaotropesDNAelectron transfernanotechnologysynthetic biology

Identifiers

PMID35245408
PMCPMC9310614
OpenAlexW4214887957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.