Evidence map›Paper›PMID 35245284›Full record

Trial reportPLoS neglected tropical diseases2022

Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela.

Audrey Lenhart, Carmen Elena Castillo, Elci Villegas, Neal Alexander, Veerle Vanlerberghe, Patrick van der Stuyft, Philip J McCall

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Efficacy of householdHeliyon · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Audrey LenhartVector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0002-9156-4228
Carmen Elena CastilloVector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Elci VillegasUniversidad de los Andes, Núcleo Rafael Rangel, Instituto Experimental Jose Witremundo Torrealba, Trujillo, Venezuela.
Neal AlexanderMRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-6707-7876
Veerle VanlerbergheDepartment of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0002-6531-0793
Patrick van der StuyftDepartment of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Philip J McCallVector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0002-0007-3985

Funding

Medical Research Council MR/R010161/1Medical Research Council MR/T001267/1
6 · The paper itself

Abstract

backgroundFollowing earlier trials indicating that their potential in dengue vector control was constrained by housing structure, a large-scale cluster-randomized trial of insecticide treated curtains (ITCs) and water jar covers (ITJCs) was undertaken in Venezuela.

methodsIn Trujillo, Venezuela, 60 clusters (6223 houses total) were randomized so that 15 clusters each received either PermaNet insecticide-treated window curtains (ITCs), permanent insecticide-treated water storage jar covers (ITJCs), a combination of both ITCs and ITJCs, or no insecticide treated materials (ITMs). A further 15 clusters located at least 5km from the edge of the study site were selected to act as an external control. Entomological surveys were carried out immediately before and after intervention, and then at 6-month intervals over the following 27 months. The Breteau and House indices were used as primary outcome measures and ovitrap indices as secondary. Negative binomial regression models were used to compare cluster-level values of these indices between the trial arms.

resultsReductions in entomological indices followed deployment of all ITMs and throughout the trial, indices in the external control arm remained substantially higher than in the ITM study arms including the internal control. Comparing the ratios of between-arm means to summarise the entomological indices throughout the study, the combined ITC+ITJC intervention had the greatest impact on the indices, with a 63% difference in the pupae per person indices between the ITC+ITJC arm and the internal control. However, coverage had fallen below 60% by 14-months post-intervention and remained below 40% for most of the remaining study period.

conclusionsITMs can impact dengue vector populations in the long term, particularly when ITCs and ITJCs are deployed in combination.

trial registrationClinicalTrials.gov ISRCTN08474420; www.isrctn.com.

Indexed as

AedesDengueInsecticidesAnimalsHumansMosquito ControlMosquito VectorsVenezuelaWaterInsecticidesWater

Identifiers

PMID35245284
PMCPMC8926262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.