ArticleScience advances2022
Cortico-striatal circuits for bilaterally coordinated movements.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Abstract Representation of Movement Parameters in Basal Ganglia Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits.Nature communications · 2026Article
- Differential cannabinergic effects on temporal perception and production.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning.Cell reports · 2025Article
- Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice.Glia · 2025Article
- Association of Increased Brain Iron Levels With Anxiety and Motor Dysfunction in Cerebral Small Vessel Disease.CNS neuroscience & therapeutics · 2025Article
- Article
- The role of motor cortex in motor sequence execution depends on demands for flexibility.Nature neuroscience · 2024Article
- Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.iScience · 2024Article
- Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences.Nature neuroscience · 2023Article
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- Biocytin-Labeling in Whole-Cell Recording: Electrophysiological and Morphological Properties of Pyramidal Neurons in CYLD-Deficient Mice.Molecules (Basel, Switzerland) · 2023Article
- Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dissecting structural connectivity of the left and right inferior frontal cortex in children who stutter.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Translational neuronal ensembles: Neuronal microcircuits in psychology, physiology, pharmacology and pathology.Frontiers in systems neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Movement initiation and control require the orchestrated activity of sensorimotor cortical and subcortical regions. However, the exact contribution of specific pathways and interactions to the final behavioral outcome are still under debate. Here, by combining structural lesions, pathway-specific optogenetic manipulations and freely moving electrophysiological recordings in rats, we studied cortico-striatal interactions in the context of forelimb bilaterally coordinated movements. We provide evidence indicating that bilateral actions are initiated by motor cortical regions where intratelencephalic bilateral cortico-striatal (bcs-IT) projections recruit the sensorimotor striatum to provide stability and duration to already commanded bilateral movements. Furthermore, striatal spiking activity was correlated with movement duration and kinematic parameters of the execution. bcs-IT stimulation affected only the representation of movement duration but spared that of kinematics. Our findings confirm the modular organization of information processing in the striatum and its involvement in moment-to-moment movement control but not initiation or selection.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.