ArticleScience advances2022
Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Advances in the differentiation of induced pluripotent stem cells into vascular cells for the treatment of diabetic microvascular disease.Cardiovascular diabetology · 2026Review
- Generation of Induced Pluripotent Stem Cells and Neuroepithelial Stem Cells from a Family with the Pathogenic Variant p.Q337X in Progranulin.International journal of molecular sciences · 2025Article
- Consistent self-organized emergence of hyaline cartilage in human induced pluripotent stem cell-derived multi-tissue organoids.Stem cells (Dayton, Ohio) · 2025Article
- Targeting Diabetic Retinopathy with Human iPSC-Derived Vascular Reparative Cells in a Type 2 Diabetes Model.Cells · 2025Article
- Dhdds T206A and Dhdds K42E knock-in mouse models of retinitis pigmentosa 59 are phenotypically similar.Disease models & mechanisms · 2025Article
- Immune-privileged cord blood-derived endothelial colony-forming cells: advancing immunomodulation and vascular regeneration.Angiogenesis · 2025Review
- Human Pluripotent Stem Cells Derived Endothelial Cells Repair Choroidal Ischemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Urine-derived stem cell therapy for diabetes mellitus and its complications: progress and challenges.Endocrine · 2024Review
- Exploring the design of clinical research studies on the efficacy mechanisms in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Review
- Cell and molecular targeted therapies for diabetic retinopathy.Frontiers in endocrinology · 2024Review
- A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission.Cell death & disease · 2023Article
- Article
Corrections and comments
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Authors and funding
24 authors at 9 institutions in 5 countries.
Chang-Hyun GilDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-8323-5064
Dibyendu ChakrabortyDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0003-3934-3249
Cristiano P VieiraDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-6937-5009
Nutan PrasainDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sergio Li CalziDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0001-8963-1519
Seth D FortmannDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-9554-8751
Ping HuDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Kimihiko BannoDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1458-0881
Mohamed JamalCenter for Regenerative Medicine, Pulmonary Center, and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-5865-7943
Chao HuangDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Micheli S SielskiDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-6682-7954
Yang LinDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0709-2468
Xinxin HuangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4298-4859
Mariana D DupontDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0001-7986-3383
Jason L FloydDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-7452-1680
Ram PrasadDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-1931-5040
Ana Leda F LonghiniDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.
Trevor J McGillDepartment of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA.ORCID 0000-0002-5616-3285
Hyung-Min ChungDepartment of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0001-5623-4875
Michael P MurphyDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Darrell N KottonCenter for Regenerative Medicine, Pulmonary Center, and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-9604-8476
Michael E BoultonDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-0796-1766
Mervin C YoderDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4354-7631
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL 35294, USA.ORCID 0000-0002-6470-0255
University of Alabama at Birmingham · USIndiana University School of MedicineBoston University · USCalifornia Institute for Regenerative Medicine · USCornell University · USFudan University · CNKonkuk University · KRMemorial Sloan Kettering Cancer Center · USOregon Health & Science University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3MVisual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MNITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6MDerivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5MA National iPS Cell Network with Deep Phenotyping for Translational ResearchU01TR001810 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILAD, YOAV, KOTTON, DARRELL N. · 2016 to 2020
$4.4MNATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL75N92020C00005 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI N/A, N/A · 2021 to 2024
$2.6MA Clinical and Histological Analysis of Mesenchymal Stem Cells in AmputationR01HL128827 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI MURPHY, MICHAEL PATRICK · 2016 to 2019
$1.8MNoninvasive Visualization and Analysis of Organ Systems using OCT and Digital FunS10RR026887 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PITTLER, STEVEN J · 2010 to 2010
$275kRole of choroidal macrophages in regulating lipid homeostasis and immunosuppression of the RPE/choroidF30EY033198 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FORTMANN, SETH D · 2021 to 2024
$180kNCATS NIH HHS U01 TR001810NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA082709NCRR NIH HHS S10 RR026887NEI NIH HHS F30 EY033198NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NHLBI NIH HHS 75N92020C00005NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL128827NIDDK NIH HHS U54 DK106846
Abstract
Human induced pluripotent stem cells (hiPSCs) were differentiated into a specific mesoderm subset characterized by KDR
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