ReviewPeriodontology 20002022
Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications.
Review in Periodontology 2000, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
248 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Influence of periodontal conditions on quality of life in patients with chronic kidney disease: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Association between smoking cessation and periodontitis progression: a systematic review and meta-analysis of prospective observational studies.Frontiers in oral health · 2026Pooled it
- The therapeutic potential of terpenes in periodontal disease: a systematic review of pre-clinical animal studies.Inflammopharmacology · 2025Pooled it
- Root Cementum Molecular Structure and Its Role in Maintaining Oral Health-Systematic Review.International journal of molecular sciences · 2025Pooled it
- Periodontitis and the Risk of Heart Failure:a Meta-analysis and Mendelian Randomisation Study.Oral health & preventive dentistry · 2025Pooled it
- Pooled it
- Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.Brazilian oral research · 2024Pooled it
- Comparative Efficacy of Platelet-Rich Fibrin and Enamel Matrix Derivative As Adjuncts to Non-Surgical Periodontal Therapy: A Split-Mouth Randomised Clinical Trial.Oral health & preventive dentistry · 2026Trial
- Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study.Respiratory research · 2025Trial
- Bioorthogonal aggregation-induced emission nanoprobes for targeted photodynamic eradication of Gram-negative pathogens in periodontitis.Materials today. Bio · 2026Article
- SIRT6 activator MDL-800 alleviates periodontal inflammation by inhibiting AIM2 pathway.Acta pharmaceutica Sinica. B · 2026Article
- Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling.Journal of clinical periodontology · 2026Article
- Periodontal Procedure Intensity and Incident Tinnitus in Korean Adults: A Nationwide Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Oral Health Status, Knowledge, Hygiene Behavior and Cognitive Function Among Older Adults in Shanghai, China.Behavioral sciences (Basel, Switzerland) · 2026Article
- Association Between Glyco-Lipid Seven-Factor Index, a Novel Composite Glyco-Lipid Index, and Periodontitis: A Cross-Sectional Study.International dental journal · 2026Article
- Association between self-reported oral symptoms and irritable bowel syndrome: A prospective cohort study based on UK Biobank.Journal of periodontology · 2026Article
- Nonsteroidal Anti-Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation.Journal of clinical periodontology · 2026Article
- Comparative Effect of Non-surgical Versus Surgical Therapy for Stage III/IV Periodontitis: A Retrospective Cohort Study.International dental journal · 2026Article
188 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.