Evidence map›Paper›PMID 35244862›Full record

ArticleStem cell reviews and reports2022

Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice.

Tatiana E Koike, Cesar S Fuziwara, Patricia C Brum, Edna T Kimura, Thomas A Rando, Elen H Miyabara

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Tatiana E KoikeDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, 2415. CEP, São Paulo, SP, 05508-000, Brazil.
Cesar S FuziwaraDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Patricia C BrumSchool of Physical Education and Sport, University of São Paulo, São Paulo, SP, Brazil.
Edna T KimuraDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Thomas A RandoVeterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, USA.
Elen H MiyabaraDepartment of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, 2415. CEP, São Paulo, SP, 05508-000, Brazil. elenm@usp.br.ORCID 0000-0002-2325-9571
Universidade de São Paulo · BRUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knockout (ko) mice for the β2 adrenoceptor (Adrβ2) have impaired skeletal muscle regeneration, suggesting that this receptor is important for muscle stem cell (satellite cell) function. Here, we investigated the role of Adrβ2 in the function of satellite cells from β2ko mice in the context of muscle regeneration, through in vivo and in vitro experiments. Immunohistochemical analysis showed a significant reduction in the number of self-renewed Pax7

Indexed as

Satellite Cells, Skeletal MuscleAnimalsbeta CateninMiceMice, KnockoutMusclesMyogeninReceptors, AdrenergicWnt Signaling Pathwaybeta CateninMyogeninReceptors, AdrenergicDifferentiationNotchProliferationSatellite cellWnt/β-cateninβ2 adrenoceptor

Identifiers

PMID35244862
OpenAlexW4214831032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.