Evidence map›Paper›PMID 35244824›Full record

ArticleMetabolic brain disease2022

Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer's disease.

Rastin Nikkar, Aghil Esmaeili-Bandboni, Mahshid Badrikoohi, Parvin Babaei

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  11. IGF-1's protective effect on OSAS rats' learning and memory.Sleep & breathing = Schlaf & Atmung · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rastin NikkarCellular &Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Aghil Esmaeili-BandboniDepartment of Medical Genetics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Mahshid BadrikoohiCellular &Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Parvin BabaeiCellular &Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. p_babaei@gums.ac.ir.ORCID http://orcid.org/0000-0003-4870-8182
Guilan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Communication between astrocytes and neurons has a profound effect on the pathophysiology of Alzheimer's disease (AD). Astrocytes regulate homeostasis and increase synaptic plasticity in physiological situations, however, they become activated during the progression of AD. Whether or not these reactions are supportive or detrimental for the central nervous system have not been understood yet. Considering epigenetic regulation of neuroinflammatory genes by chromatin readers, particularly bromodomain and extraterminal domain (BET) family, here we examined the effect of chronic co-inhibition of astrocytes metabolism (with fluorocitrate) and also BRD4 (with JQ1) on cognition deficit at early stages of AD. Forty adult male Wistar rats underwent stereotaxic cannulation for inducing AD by intrahippocampal injection of Aβ

Indexed as

Alzheimer DiseaseSpatial MemoryAmyloid beta-PeptidesAnimalsAstrocytesChromatinCyclic AMP Response Element-Binding ProteinDimethyl SulfoxideEpigenesis, GeneticMaleNuclear ProteinsRatsRats, WistarSynaptophysinTumor Necrosis Factor-alphaAmyloid beta-PeptidesChromatinCyclic AMP Response Element-Binding ProteinDimethyl SulfoxideNuclear ProteinsSynaptophysinTumor Necrosis Factor-alphaAlzheimer’s diseaseAstrocytesCognition deficitCREBEpigeneticsPSD95

Identifiers

PMID35244824
OpenAlexW4214878100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.