ArticleThe American journal of clinical nutrition2022
Sex-related association of nonalcoholic fatty liver disease and liver fibrosis with body fat distribution in the general US population.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 58 citations in OpenAlex.
- Sex Steroids Regulate Liver Fat Content and Body Fat Distribution in Both Men and Women: A Study in Transgender Persons.The Journal of clinical endocrinology and metabolism · 2023Trial
- Lifestyle mediates the association between normal-weight visceral obesity and MASLD in older adults with hypertension and diabetes.Frontiers in nutrition · 2026Article
- Dysregulated high-density lipoprotein and low-density lipoprotein subfractions increase metabolic dysfunction-associated steatotic liver disease risk: a study of patients across body mass index categories.Frontiers in nutrition · 2026Article
- Association between TyG index and MASLD in lean young adults: a retrospective study.BMC endocrine disorders · 2025Article
- Diagnostic and prognostic value of adipose tissue content and distribution indicators for normal weight obesity in young women.Scientific reports · 2025Article
- Body muscle mass versus fat mass: gender-specific associations with NAFLD and liver fibrosis.Lipids in health and disease · 2025Article
- Ethnic heterogeneity in steatosis-driven liver injury among MASLD patients: Han Chinese vs. Caucasian.Clinical and experimental hepatology · 2025Article
- Association between body fat distribution and female stress urinary incontinence: a cross-sectional study with the NHANES 2011-2018.Translational andrology and urology · 2025Article
- Iron Homeostasis as a Mediator Linking Central Obesity with MASLD and Primary Liver Cancer: A Two-Step Mendelian Randomization Study.Biomedicines · 2025Article
- Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis.Cell discovery · 2025Article
- Article
- Impact of segmental body composition on metabolicFrontiers in endocrinology · 2025Article
- Article
- Imaging-based body fat distribution and diabetic retinopathy in general US population with diabetes: an NHANES analysis (2003-2006 and 2011-2018).Nutrition & diabetes · 2024Article
- Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study.The journal of nutrition, health & aging · 2024Article
- The association between non-alcoholic fatty liver disease and urinary incontinence among adult females in the United States.BMC public health · 2024Article
- Waistline to thigh circumference ratio as a predictor of MAFLD: a health care worker study with 2-year follow-up.BMC gastroenterology · 2024Article
- Associations Between Active, Passive Smoking and the Risk of Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2024Article
- Association between the ZJU index and risk of new-onset non-alcoholic fatty liver disease in non-obese participants: a Chinese longitudinal prospective cohort study.Frontiers in endocrinology · 2024Article
- Association between TyG index trajectory and new-onset lean NAFLD: a longitudinal study.Frontiers in endocrinology · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew population-based studies have investigated the association between body fat distribution and the risk of nonalcoholic fatty liver disease (NAFLD) and significant liver fibrosis.
objectivesWe aimed to evaluate the relations of total body fat and body fat distribution with NAFLD in the general US population.
methodsThis is a cross-sectional, population-based study based on the 2017-2018 cycle of the NHANES. Participants aged 18-59 y without known liver conditions or significant alcohol consumption were studied by DXA and vibration-controlled transient elastography to assess body composition and liver steatosis and fibrosis, respectively. Multivariable logistic regression analysis was performed to evaluate the contribution of BMI and android:gynoid ratio (A:G ratio) to the prevalence of liver steatosis and fibrosis in males and females.
resultsWeighted prevalence of steatosis was 41.5% and 29.9% among the 1115 males and 1113 females included in the study, respectively, whereas 7.0% of males and 4.0% of females had elastographic evidence of significant liver fibrosis. After adjustment for age, race-Hispanic origin, diabetes, cigarette smoke, and BMI, a higher A:G ratio was associated with increased odds of steatosis in both males (OR: 1.79; 95% CI: 1.07, 2.99; P = 0.029) and females (OR: 1.95; 95% CI: 1.11, 3.41; P = 0.023). Conversely, a significant association between A:G ratio and liver fibrosis was identified in females (OR: 2.09; 95% CI: 1.11, 3.97; P = 0.026), but not in males (OR: 0.56; 95% CI: 0.29, 1.08; P = 0.078).
conclusionsIndependently from BMI, an android fat deposition pattern is associated with increased prevalence of NAFLD in both sexes, whereas the effect on fibrosis was only evident in females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.