ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
Assessment of arterial stiffness to predict blood pressure response to renal sympathetic denervation.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patient-Specific Factors Predicting Renal Denervation Response in Patients With Hypertension: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2024Pooled it
- Effects of sympathomodulation on pulse wave properties in heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Accuracy of wearable smartwatch for measuring blood pressure and oxygen saturation across a wide altitudinal gradient: a comparative study in Migrant and Resident populations.Frontiers in physiology · 2026Article
- Autonomic control of the vasculature in CKD: leveraging renal denervation.Frontiers in neuroscience · 2026Review
- Association between arterial stiffness and long-term efficacy of renal sympathetic denervation: 5-year results of the ASORAS study.Cardiovascular intervention and therapeutics · 2026Article
- Renal Denervation in Asia: 2025 Asia Renal Denervation Consortium (ARDeC) Consensus Statement Endorsed by the Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Renal Denervation After USA FDA Approval: An Update from an Interventional Cardiologist's Perspective.Journal of clinical medicine · 2025Review
- Response of Blood Pressure to Renal Denervation Is Not Associated With Genetic Variants.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Renal nerves in physiology, pathophysiology and interoception.Nature reviews. Nephrology · 2025Review
- Novel approaches to define responders to interventional treatment in hypertension: insights from the SPYRAL HTN-OFF and HTN-ON MED trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Advances on the Experimental Research in Resistant Hypertension.Current hypertension reports · 2024Review
- Skin sodium content as a predictor of blood pressure response to renal denervation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Article
- Twenty-Four-Month Blood Pressure Results After Renal Denervation Using Endovascular Ultrasound.Journal of the American Heart Association · 2023Article
- Predicting Renal Denervation Response in Resistant High Blood Pressure by Arterial Stiffness Assessment: A Systematic Review.Journal of clinical medicine · 2022Review
- Autonomic nervous system: an integrative regulator in circadian rhythm of blood pressure.Frontiers in neurologyReview
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent trials support the efficacy of renal sympathetic denervation (RDN) to reduce blood pressure (BP). Nevertheless, about one third of patients are considered non-responders to RDN. Previous retrospective analyses suggest arterial stiffness could predict BP response to RDN.
aimsWe prospectively assessed the potential of invasive pulse wave velocity (iPWV) to predict BP response to RDN. Additionally, we aimed to establish non-invasive models based on arterial stiffness to predict BP response to RDN.
methodsiPWV, magnetic resonance imaging-based markers of arterial stiffness and the carotid-femoral pulse wave velocity were recorded prior to RDN in patients with treatment resistant hypertension. Changes in daytime BP after 3 months were analysed according to the prespecified iPWV cut-off (14.4 m/s). Regression analyses were used to establish models for non-invasive prediction of BP response. Results were compared to iPWV as reference and were then validated in an external patient cohort.
resultsEighty patients underwent stiffness assessment before RDN. After 3 months, systolic 24h and daytime BP were reduced by 13.6±9.8 mmHg and 14.7±10.6 mmHg in patients with low iPWV, versus 6.2±13.3 mmHg and 6.3±12.8 mmHg in those with high iPWV (p<0.001 for both). Upon regression analysis, logarithmic ascending aortic distensibility and systolic baseline BP independently predicted BP change at follow-up. Both were confirmed in the validation cohort.
conclusionsiPWV is an independent predictor for BP response after RDN. In addition, BP change prediction following RDN using non-invasive measures is feasible. This could facilitate patient selection for RDN treatment.
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