ReviewBipolar disorders2022
Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.
Review in Bipolar disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Prescription Trends for Bipolar Disorder With and Without Comorbid Substance Use and Anxiety Disorders: A Global Bipolar Cohort Collaborative Study.Bipolar disorders · 2026Article
- Addressing the unmet needs of bipolar disorder in Australia and beyond.The Australian and New Zealand journal of psychiatry · 2025Article
- Integrating Knowledge: The Power of Ontologies in Psychiatric Research and Clinical Informatics.Biological psychiatry · 2025Review
- Predominant Polarity for Enhanced Phenotyping and Personalized Treatment of Bipolar Disorder: A Narrative Review on Recent Findings.Current psychiatry reports · 2025Review
- The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states.Learning health systems · 2025Article
- Forging a learning health system for early psychosis: Insights from the academic community EPINET.Schizophrenia research · 2025Article
- Person-Specific Analyses of Smartphone Use and Mental Health: Intensive Longitudinal Study.JMIR formative research · 2025Article
- Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics.iScience · 2024Article
- Patterns of pharmacotherapy for bipolar disorder: A GBC survey.Bipolar disorders · 2024Article
- Biomarkers in psychiatric disorders: status quo, impediments and facilitators.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Biomarkers for clinical use in psychiatry: where are we and will we ever get there?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Childhood trauma and depressive symptoms in bipolar disorder: A network analysis.Acta psychiatrica Scandinavica · 2023Article
- Editorial: Comorbidity in bipolar disorder, volume II.Frontiers in psychiatry · 2023Article
- A critical evaluation of dynamical systems models of bipolar disorder.Translational psychiatry · 2022Review
- Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.Bipolar disorders · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Bipolar disorder (BD) is a complex and dynamic condition with a typical onset in late adolescence or early adulthood followed by an episodic course with intervening periods of subthreshold symptoms or euthymia. It is complicated by the accumulation of comorbid medical and psychiatric disorders. The etiology of BD remains unknown and no reliable biological markers have yet been identified. This is likely due to lack of comprehensive ontological framework and, most importantly, the fact that most studies have been based on small nonrepresentative clinical samples with cross-sectional designs. We propose to establish large, global longitudinal cohorts of BD studied consistently in a multidimensional and multidisciplinary manner to determine etiology and help improve treatment. Herein we propose collection of a broad range of data that reflect the heterogenic phenotypic manifestations of BD that include dimensional and categorical measures of mood, neurocognitive, personality, behavior, sleep and circadian, life-story, and outcomes domains. In combination with genetic and biological information such an approach promotes the integrating and harmonizing of data within and across current ontology systems while supporting a paradigm shift that will facilitate discovery and become the basis for novel hypotheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.