Evidence map›Paper›PMID 35244302›Full record

ArticleJournal of magnetic resonance imaging : JMRI2022

Pediatric

Matthew M Willmering, Laura L Walkup, Peter J Niedbalski, Hui Wang, Ziyi Wang, Erik B Hysinger, Kasiani C Myers, Christopher T Towe, Bastiaan Driehuys, Zackary I Cleveland and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  4. A thermally polarized, dissolved-phaseJournal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Initial feasibility and challenges of hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  9. Article
  10. Image Phenotyping of Preterm-Born Children Using HyperpolarizedAmerican journal of respiratory and critical care medicine · 2023
    Article
  11. Review
  12. Seeing Premature Lung Disease: Hyperpolarized Xe Magnetic Resonance Imaging.American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Matthew M WillmeringCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-4356-9622
Laura L WalkupCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Peter J NiedbalskiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Hui WangMR Clinical Science, Philips, Cincinnati, Ohio, USA.
Ziyi WangDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Erik B HysingerCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kasiani C MyersDepartment of Pediatrics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Christopher T ToweCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Bastiaan DriehuysDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-1236-4210
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jason C WoodsCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-8080-7511
Cincinnati Children's Hospital Medical Center · USDuke University · USPhilips (United States) · US

Funding

UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
Early detection of regional BOS in BMT patients using UTE and 129Xe MRIR00HL138255 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WALKUP, LAURA LEE · 2020 to 2022
$747k
NHLBI NIH HHS R00 HL138255NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

backgroundPURPOSE/HYPOTHESIS: To perform an exploratory analysis of STUDY TYPE: Prospective. POPULATION: Seventy-seven human volunteers (38 males, age = 17.7 ± 15.1 years, range 5-68 years, 16 healthy). Four pediatric disease cohorts. FIELD STRENGTH/SEQUENCE: 3-T, three-dimensional-radial one-point Dixon Fast Field Echo (FFE) Ultrashort Echo Time (UTE). ASSESSMENT: Breath hold compliance was assessed by quantitative signal-to-noise and dynamic metrics. Whole-lung means and standard deviations were extracted from gas-transfer maps. Gas-transfer metrics were investigated with respect to age and lung disease. Clinical pulmonary function tests were retrospectively acquired for reference lung disease severity. STATISTICAL TESTS: Wilcoxon rank-sum tests to compare age and disease cohorts, Wilcoxon signed-rank tests to compare pre- and post-breath hold vitals, Pearson correlations between age and gas-transfer metrics, and limits of normal with a binomial exact test to compare fraction of subjects with abnormal gas-transfer. P ≤ 0.05 was considered significant.

resultsEighty percentage of pediatric subjects successfully completed DATA

conclusionPediatric LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 2.

Indexed as

Lung DiseasesXenon IsotopesAdolescentAdultAgedChildChild, PreschoolFeasibility StudiesHumansImaging, Three-DimensionalInfant, NewbornLungMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesXenonXenon Isotopes129Xeexchangegas transferinterstitial lung diseasepediatricpulmonary

Identifiers

PMID35244302
PMCPMC9519191
OpenAlexW4214863976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.