Evidence map›Paper›PMID 35244217›Full record

ArticleThe Journal of physiology2022

The HVCN1 voltage-gated proton channel contributes to pH regulation in canine ventricular myocytes.

Jianyong Ma, Xiaoqian Gao, Yutian Li, Thomas E DeCoursey, Gary E Shull, Hong-Sheng Wang

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Hv1 channel in immune cells and pharmacology.Pharmacological research · 2025
    Review
  3. CaBiomolecules · 2025
    Review
  4. Transcendent Aspects of Proton Channels.Annual review of physiology · 2024
    Review
  5. Article
  6. Inhibition of the HFrontiers in immunology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. The Voltage-Gated Hv1 HInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Channelling protons out of the heart.The Journal of physiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jianyong MaDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Xiaoqian GaoDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yutian LiDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Thomas E DeCourseyDepartment of Physiology and Biophysics, Rush University, Chicago, IL, USA.ORCID 0000-0002-4263-180X
Gary E ShullDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0001-7654-6016
Hong-Sheng WangDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
University of Cincinnati Medical Center · USRush University · US

Funding

Endocrine Disruptors and Heart HealthR01ES027855 · NIEHS · UNIVERSITY OF CINCINNATI · PI RUBINSTEIN, JACK, WANG, HONG-SHENG · 2018 to 2022
$2.1M
Control Mechanisms of Human Voltage Gated Proton Channels, hHv1R35GM126902 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI DECOURSEY, THOMAS E · 2018 to 2022
$1.8M
Effects of environmental estrogen exposure on the heartR01ES017263 · NIEHS · UNIVERSITY OF CINCINNATI · PI WANG, HONG-SHENG · 2009 to 2013
$1.7M
NIEHS NIH HHS R01 ES017263NIEHS NIH HHS R01 ES027855NIGMS NIH HHS R35 GM126902
6 · The paper itself

Abstract

Regulation of intracellular pH (pH

Indexed as

Myocytes, CardiacProtonsAcidsAnimalsBicarbonatesCarbon DioxideDogsHydrogen-Ion ConcentrationSodiumSodium-Hydrogen ExchangersAcidsBicarbonatesCarbon DioxideProtonsSodiumSodium-Hydrogen Exchangerscardiac myocytesHv1HVCN1intracellular pHproton channelSLC9A1

Identifiers

PMID35244217
PMCPMC9058222
OpenAlexW4214947244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.