Evidence map›Paper›PMID 35244194›Full record

ArticleMolecular medicine reports2022

Co‑expressed microRNAs, target genes and pathways related to metabolism, inflammation and endocrine function in individuals at risk for type 2 diabetes.

Elena Flowers, Kesava Asam, Isabel Elaine Allen, Alka M Kanaya, Bradley E Aouizerat

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review of databases for experimentally validated human microRNA-mRNA interactions.Database : the journal of biological databases and curation · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Elena FlowersDepartment of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143‑0610, USA.
Kesava AsamBluestone Center for Clinical Research, New York University, New York, NY 10010, USA.
Isabel Elaine AllenDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143‑0610, USA.
Alka M KanayaDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143‑0610, USA.
Bradley E AouizeratBluestone Center for Clinical Research, New York University, New York, NY 10010, USA.
University of California, San Francisco · USCenter for Clinical Research (United States) · USNew York University · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) studyR01AT004569 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2009 to 2012
$2.1M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
Evaluating Longitudinal Relationships Between Circulating MicroRNAs and Risk for Type 2 Diabetes and Responses to Behavioral InterventionsR21DK117346 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLOWERS, ELENA · 2018 to 2020
$603k
NCATS NIH HHS KL2 TR000143NCCIH NIH HHS R01 AT004569NHLBI NIH HHS K24 HL112827NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK092924NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R21 DK117346
6 · The paper itself

Abstract

MicroRNAs (miRNAs) may be considered important regulators of risk for type 2 diabetes (T2D). The aim of the present study was to identify novel sets of miRNAs associated with T2D risk, as well as their gene and pathway targets. Circulating miRNAs (n=59) were measured in plasma from participants in a previously completed clinical trial (n=82). An agnostic statistical approach was applied to identify novel sets of miRNAs with optimal co‑expression patterns.

Indexed as

Biological PhenomenaDiabetes Mellitus, Type 2MicroRNAsGene Expression ProfilingHumansInflammationRNA, MessengerMicroRNAsRNA, MessengerbiomarkerdiabetesFBGmiRNApathway analysis

Identifiers

PMID35244194
PMCPMC8941378
OpenAlexW4214915031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.