ArticleCerebral cortex (New York, N.Y. : 1991)2023
Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct.Psychopharmacology · 2024Pooled it
- Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions.Annual review of psychology · 2026Review
- Subtypes of cocaine use disorder and their neurobehavioral profiles.Translational psychiatry · 2025Article
- Systematic Review and Meta-analysis of the Impact of Cocaine Use on Cognitive Inhibition.Neuropsychology review · 2025Review
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.Molecular psychiatry · 2024Article
- Pump the brakes: identifying neurobiological targets to enhance inhibitory control in drug addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction.The American journal of psychiatry · 2024Article
- Article
- The Neural Signature of Impaired Inhibitory Control in Individuals with Heroin Use Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- An electroencephalography connectome predictive model of craving for methamphetamine.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionDrug addiction is characterized by impaired response inhibition and salience attribution (iRISA), where the salience of drug cues is postulated to overpower that of other reinforcers with a concomitant decrease in self-control. However, the neural underpinnings of the interaction between the salience of drug cues and inhibitory control in drug addiction remain unclear.
methodsWe developed a novel stop-signal functional magnetic resonance imaging task where the stop-signal reaction time (SSRT-a classical inhibitory control measure) was tested under different salience conditions (modulated by drug, food, threat, or neutral words) in individuals with cocaine use disorder (CUD; n = 26) versus demographically matched healthy control participants (n = 26).
resultsDespite similarities in drug cue-related SSRT and valence and arousal word ratings between groups, dorsolateral prefrontal cortex (dlPFC) activity was diminished during the successful inhibition of drug versus food cues in CUD and was correlated with lower frequency of recent use, lower craving, and longer abstinence (Z > 3.1, P < 0.05 corrected). DISCUSSION: Results suggest altered involvement of cognitive control regions (e.g. dlPFC) during inhibitory control under a drug context, relative to an alternative reinforcer, in CUD. Supporting the iRISA model, these results elucidate the direct impact of drug-related cue reactivity on the neural signature of inhibitory control in drug addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.