Evidence map›Paper›PMID 35243620›Full record

Trial reportActa psychiatrica Scandinavica2022

Childhood trauma and treatment outcomes during mood-stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder.

Anna L Wrobel, Ole Köhler-Forsberg, Louisa G Sylvia, Samantha E Russell, Olivia M Dean, Sue M Cotton, Michael Thase, Joseph R Calabrese, Thilo Deckersbach, Mauricio Tohen and 11 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Probing neuropsychiatric disorders through in vivo CRISPR screening.Current opinion in genetics & development · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 4 countries.

Anna L WrobelIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-1864-0394
Ole Köhler-ForsbergPsychosis Research Unit, Aarhus University Hospital Psychiatry, Aarhus, Denmark.ORCID 0000-0001-5121-1287
Louisa G SylviaDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Samantha E RussellIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Olivia M DeanIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Sue M CottonOrygen, Parkville, Victoria, Australia.
Michael ThaseDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joseph R CalabreseDepartment of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA.
Thilo DeckersbachDiploma Hochschule, University of Applied Sciences, Bad Sooden-Allendorf, Germany.
Mauricio TohenDepartment of Psychiatry, University of New Mexico Health Science Center, Albuquerque, New Mexico, USA.
Charles L BowdenDepartment of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
James H KocsisDepartment of Psychiatry, Weill Cornell Medical College, New York, New York, USA.
Edward S FriedmanDepartment of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Terence A KetterDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Richard C SheltonDepartment of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Michael J OstacherDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-0353-7535
Dan V IosifescuNYU School of Medicine and Nathan Kline Institute, New York, New York, USA.
Michael BerkIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946
Alyna TurnerIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Andrew A NierenbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Deakin University · AUHarvard University · USCase Western Reserve University · USCornell University · USDiploma Hochschule · DENathan Kline Institute for Psychiatric Research · USStanford University · USThe Royal Melbourne Hospital · AUThe University of Melbourne · AUThe University of Texas Health Science Center at San Antonio · USUniversity of Alabama at Birmingham · USUniversity of Michigan · USUniversity of New Mexico · USUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · USVA Palo Alto Health Care System · US

Funding

Comparative Effectiveness Study for Bipolar DisorderR01HS019371 · AHRQ · MASSACHUSETTS GENERAL HOSPITAL · PI NIERENBERG, ANDREW A · 2010 to 2010
$9.8M
AHRQ HHS R01 HS019371
6 · The paper itself

Abstract

backgroundChildhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipolar disorder remains understudied.

methodsThe effect of childhood trauma on treatment outcomes was evaluated among participants randomised to treatment with lithium or quetiapine in the Clinical and Health Outcomes Initiatives in Comparative Effectiveness for Bipolar Disorder (Bipolar CHOICE) study by clinician assessment. Mixed effects linear regression models were used to analyse rates of improvement in symptom severity (assessed with the Bipolar Inventory of Symptoms Scale and the Clinical Global Impression Scale for Bipolar Disorder) and functional impairment (assessed with the Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool).

resultsA history of any childhood trauma was reported by 52.7% of the sample (N = 476). Although participants with a history of any childhood trauma presented with greater symptom severity and functional impairment at most study visits, participants with and without a history of any childhood trauma showed similar rates of improvement in symptom severity and functional impairment over the 24 weeks of treatment.

conclusionThis is the first study to explore the association between childhood trauma and treatment outcomes during treatment with lithium or quetiapine in the context of a randomised trial. In Bipolar CHOICE, a history of childhood trauma did not inhibit improvement in symptom severity or functional impairment. Nevertheless, these findings need replication across different settings.

Indexed as

Adverse Childhood ExperiencesAntipsychotic AgentsBipolar DisorderHumansLithiumOutpatientsQuetiapine FumarateTreatment OutcomeAntipsychotic AgentsLithiumQuetiapine Fumaratebipolar disorderchildhood abuselithiumquetiapinetreatment outcomes

Identifiers

PMID35243620
PMCPMC9310642
OpenAlexW4214920529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.