Observational studyAnaesthesia2022
Cardiovascular subphenotypes in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a single-centre retrospective observational study.
Observational study in Anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Lung-Cardiovascular Interactions and Derangements in ARDS.Comprehensive physiology · 2026Review
- Right ventricular-protective ventilation in acute respiratory distress syndrome: phenotypes, monitoring and ventilatory management.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- COVID-19 vaccination and mortality among coronary care patients with severe acute respiratory infection in Bangladesh: a prospective study (2021-2024).The Lancet regional health. Southeast Asia · 2026Article
- Prevalence and prognosis impact of right ventricular injury in patients with acute respiratory distress syndrome: a systematic review and meta-analysis.Annals of intensive care · 2026Article
- Evaluation and Management of Sepsis in Pulmonary Hypertension.Journal of intensive care medicine · 2025Review
- Clinical Phenotyping in Acute Respiratory Distress Syndrome: Steps Towards Personalized Medicine.Journal of clinical medicine · 2025Article
- Acute Respiratory Distress Syndrome: Pathophysiological Insights, Subphenotypes, and Clinical Implications-A Comprehensive Review.Journal of clinical medicine · 2025Review
- Clustering and visualisation of the GABRIEL network expertise in the field of infectious diseases.BMJ global health · 2025Article
- The Effect of Prone Position on Right Ventricular Functions in CARDS: Is Survival Predictable when Evaluated Through Transesophageal Echocardiography?Turkish journal of anaesthesiology and reanimation · 2025Article
- Definition and management of right ventricular injury in adult patients receiving extracorporeal membrane oxygenation for respiratory support using the Delphi method: a PRORVnet study. Expert position statements.Intensive care medicine · 2024Article
- Heart-lung crosstalk in acute respiratory distress syndrome.Frontiers in physiology · 2024Review
- Echocardiographic parameters in COVID-19 patients and their association with ICU mortality: a prospective multicenter observational study.The ultrasound journal · 2023Article
- Literature Review-Transthoracic Echocardiography, Computed Tomography Angiography, and Their Value in Clinical Decision Making and Outcome Predictions in Patients with COVID-19 Associated Cardiovascular Complications.International journal of environmental research and public health · 2023Review
- Cardiovascular Subphenotypes in ARDS: Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes.Journal of clinical medicine · 2023Review
- The impact of COVID-19 and COVID vaccination on cardiovascular outcomes.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Usefulness and limitations of the acute respiratory distress syndrome definitions in non-intubated patients. A narrative review.Frontiers in medicine · 2023Review
- Acute Respiratory Distress Syndrome in Patients with Cardiovascular Disease.Methodist DeBakey cardiovascular journal · 2023Review
- Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients.Annals of intensive care · 2022Article
- Protecting the right ventricle in COVID-19 pneumonitis: a missing piece of the puzzle?Anaesthesia · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unsupervised clustering methods of transthoracic echocardiography variables have not been used to characterise circulatory failure mechanisms in patients with COVID-19 pneumonitis. We conducted a retrospective, single-centre cohort study in ICU patients with COVID-19 pneumonitis whose lungs were mechanically ventilated and who underwent transthoracic echocardiography between March 2020 and May 2021. We performed latent class analysis of echocardiographic and haemodynamic variables. We characterised the identified subphenotypes by comparing their clinical parameters, treatment responses and 90-day mortality rates. We included 305 patients with a median (IQR [range]) age 59 (49-66 [16-83]) y. Of these, 219 (72%) were male, 199 (65%) had moderate acute respiratory distress syndrome and 113 (37%) did not survive more than 90 days. Latent class analysis identified three cardiovascular subphenotypes: class 1 (52%; normal right ventricular function); class 2 (31%; right ventricular dilation with mostly preserved systolic function); and class 3 (17%; right ventricular dilation with systolic impairment). The three subphenotypes differed in their clinical characteristics and response to prone ventilation and outcomes, with 90-day mortality rates of 22%, 42% and 73%, respectively (p < 0.001). We conclude that the identified subphenotypes aligned with right ventricular pathophysiology rather than the accepted definitions of right ventricular dysfunction, and these identified classifications were associated with clinical outcomes.
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