Evidence map›Paper›PMID 35243610›Full record

ArticleActa psychiatrica Scandinavica2022

Attachment insecurity partially mediates the relationship between childhood trauma and depression severity in bipolar disorder.

Anna L Wrobel, Samantha E Russell, Anuradhi Jayasinghe, Mojtaba Lotfaliany, Alyna Turner, Olivia M Dean, Sue M Cotton, Claudia Diaz-Byrd, Anastasia K Yocum, Elizabeth R Duval and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Adverse childhood experiences, personality traits and internalising disorder among adolescents in Nigeria.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Anna L WrobelIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-1864-0394
Samantha E RussellIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Anuradhi JayasingheOrygen, Parkville, Victoria, Australia.
Mojtaba LotfalianyIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Alyna TurnerIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Olivia M DeanIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.
Sue M CottonOrygen, Parkville, Victoria, Australia.
Claudia Diaz-ByrdDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Anastasia K YocumDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Elizabeth R DuvalDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Tobin J EhrlichDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-8066-2044
David F MarshallDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Michael BerkIMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-5554-6946
Melvin G McInnisDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Deakin University · AUUniversity of Michigan · USThe Royal Melbourne Hospital · AUThe University of Melbourne · AU

Funding

Neural Mechanisms Involved in Contextual Processing in PTSDK23MH109762 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUVAL, ELIZABETH · 2017 to 2021
$759k
NIMH NIH HHS K23 MH109762
6 · The paper itself

Abstract

backgroundChildhood trauma is associated with greater depression severity among individuals with bipolar disorder. However, the mechanisms that explain the link between childhood trauma and depression severity in bipolar disorder remain poorly understood. The mediational role of attachment insecurity in childhood and adulthood was assessed in the current study.

methodsParticipants with bipolar disorder (N = 143) completed measures of childhood trauma (Childhood Trauma Questionnaire), attachment insecurity (Experiences in Close Relationships Scale) and depression severity (Hamilton Depression Rating Scale) as part of the Prechter Longitudinal Study of Bipolar Disorder. A sequential mediation model was tested using path analysis: the direct and indirect effects of childhood trauma on depression severity with attachment insecurity (attachment anxiety and avoidance) in childhood (mother and father) and adulthood (partner) as mediators were estimated.

resultsThe final path model demonstrated an excellent fit to the data (comparative fit index = 0.996; root mean square error of approximation = 0.021 [90% confidence interval = 0.000-0.073]). Supporting the hypothesised sequential mediation model, maternal attachment anxiety in childhood and romantic attachment avoidance in adulthood partially mediated the relationship between childhood trauma and depression severity; this effect accounted for 12% of the total effect of childhood trauma on depression severity.

conclusionAttachment insecurity in childhood and adulthood form part of the complex mechanism informing why people with bipolar disorder who have a history of childhood trauma experience greater depression severity. Addressing attachment insecurity represents a valuable psychotherapeutic treatment target for bipolar disorder.

Indexed as

Adverse Childhood ExperiencesBipolar DisorderAdultAnxietyDepressionFemaleHumansLongitudinal StudiesObject Attachmentattachmentbipolar disorderchildhood abusedepressiontreatment outcomes

Identifiers

PMID35243610
PMCPMC9314952
OpenAlexW4214805506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.