Evidence map›Paper›PMID 35243536›Full record

ArticlePediatric nephrology (Berlin, Germany)2022

Cognitive and academic outcomes in children with chronic kidney disease.

Siah Kim, Anita Van Zwieten, Jennifer Lorenzo, Rabia Khalid, Suncica Lah, Kerry Chen, Madeleine Didsbury, Anna Francis, Steven Mctaggart, Amanda Walker and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Siah KimCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia. Siah.kim@health.nsw.gov.au.ORCID 0000-0003-3964-2046
Anita Van ZwietenCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Jennifer LorenzoKids Neuroscience Centre, The Children's Hospital at Westmead, Sydney, Australia.
Rabia KhalidCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Suncica LahSchool of Psychology, The University of Sydney, Sydney, Australia.
Kerry ChenCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Madeleine DidsburyCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Anna FrancisCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Steven MctaggartChild & Adolescent Renal Service, Queensland Children's Hospital, Brisbane, Australia.
Amanda WalkerDepartment of Renal Medicine, The Royal Children's Hospital, Melbourne, Australia.
Fiona E MackieDepartment of Nephrology, Sydney Children's Hospital at Randwick, Sydney, Australia.
Chanel PrestidgeDepartment of Nephrology, Starship Children's Hospital, Auckland, New Zealand.
Armando Teixeira-PintoCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Allison TongCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Katrina BlazekCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Belinda BartonChildren's Hospital Education Research Institute, The Children's Hospital at Westmead, Sydney, Australia.
Jonathan C CraigCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.
Germaine WongCentre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew data exist on the cognitive and academic functioning of children with chronic kidney disease (CKD) over the trajectory of their illness. We aimed to determine the association between CKD stages and cognitive and academic performance in children over time.

methodsWe included 53 participants (aged 6-18 years) with CKD stages 1-5 (n = 37), on dialysis (n = 3), or with functioning kidney transplant (n = 22) from three units in Australia from 2015 to 2019. Participants undertook a series of psychometric tests and were invited for repeated assessments annually. We used linear regression and linear mixed models to investigate the effect of CKD stage, adjusted for socioeconomic status.

resultsAt baseline, full-scale intelligence quotient (FSIQ) (95%CI) of children on kidney replacement therapy (KRT) was in the low average range (87: 78, 96) and average (101: 95, 108) for children with CKD 1-5. Mean (95%CI) FSIQ, word reading, numerical operations, and spelling scores for children on KRT were 14.3 (- 25.3, - 3.3), 11 (- 18.5, - 3.6), 8.5 (- 17.6, 0.76), and 10 (- 18.6, - 1.3) points lower than children with CKD Stages 1-5. Spelling and numerical operations scores declined by 0.7 (- 1.4, - 0.1) and 1.0 (- 2.0, 0.2) units per year increase in age, regardless of CKD stage.

conclusionsChildren treated with KRT have low average cognitive abilities and lower academic performance for numeracy and literacy compared to both children with CKD 1-5 and to the general population. However, the rate of decline in academic performance over time is similar for children across the full spectrum of CKD. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Renal DialysisRenal Insufficiency, ChronicChildCognitionHumansIntelligence TestsRenal Replacement TherapyAcademic achievementCKDCognitionPaediatric

Identifiers

PMID35243536
PMCPMC9489550

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.