Evidence map›Paper›PMID 35243443›Full record

ArticleHeart rhythm O22022

Personalized pacing for diastolic dysfunction and heart failure with preserved ejection fraction: Design and rationale for the

Margaret Infeld, Kramer Wahlberg, Jillian Cicero, Sean Meagher, Nicole Habel, Anand Muthu Krishnan, Daniel N Silverman, Daniel L Lustgarten, Markus Meyer

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05766462 (Utilization of Personalized Pacing to Improve Quality of Life in Sinus Node Dysfunction Patients), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05766462 completednot on this mapstarted 2023, after this paper: background citation

Utilization of Personalized Pacing to Improve Quality of Life in Sinus Node Dysfunction Patients

TypeobservationalSponsorMedtronic Cardiac Rhythm and Heart FailureRan2023 to 2025Enrolled73ConditionsSinus Node DysfunctionArmsPacemaker lower rate setting
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Personalized accelerated physiologic pacing.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Margaret InfeldDepartment of Medicine, University of Vermont, Burlington, Vermont.
Kramer WahlbergDepartment of Medicine, University of Vermont, Burlington, Vermont.
Jillian CiceroDepartment of Medicine, University of Vermont, Burlington, Vermont.
Sean MeagherDepartment of Medicine, University of Vermont, Burlington, Vermont.
Nicole HabelDepartment of Medicine, University of Vermont, Burlington, Vermont.
Anand Muthu KrishnanDepartment of Medicine, University of Vermont, Burlington, Vermont.
Daniel N SilvermanDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Daniel L LustgartenDepartment of Medicine, University of Vermont, Burlington, Vermont.
Markus MeyerDepartment of Medicine, University of Vermont, Burlington, Vermont.
University of Vermont · USMedical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with pacemakers and heart failure with preserved ejection fraction (HFpEF) or isolated diastolic dysfunction (DD) may benefit from a higher backup heart rate (HR) setting compared with the standard setting of 60 bpm.

objectiveThe purpose of this study was to assess the effects of a personalized backup HR setting (

methodsIn this prospective, blinded, randomized controlled study, pacemaker patients with DD or HFpEF and atrial pacing with intrinsic ventricular conduction or conduction system or biventricular pacing are randomized to the

resultsEnrollment began in July 2019. As of November 2020, 107 subjects have been enrolled. It is projected that the 1-year follow-up will be completed by December 2021.

conclusionAtrial pacing with intrinsic ventricular conduction or advanced ventricular pacing at a higher, personalized backup HR may be a therapeutic target for patients with isolated DD or HFpEF. The

Indexed as

Diastolic dysfunctionHeart failure with preserved ejection fractionHeart ratePacing

Identifiers

PMID35243443
PMCPMC8859799
OpenAlexW4200272900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.