ArticleCell reports. Medicine2022
Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli.
Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06787222 (Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome), which is not on this map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review.Dermatology and therapy · 2026Pooled it
- Oral Probiotics inMedicina (Kaunas, Lithuania) · 2025Pooled it
- Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Pooled it
- Using probiotics to treat acne vulgaris: systematic review.Archives of dermatological research · 2024Pooled it
- Effect of combined probiotics and doxycycline therapy on the gut-skin axis in rosacea.mSystems · 2024Trial
- Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research.Signal transduction and targeted therapy · 2026Review
- A Microbial Formulation Perspective on Probiotic Skincare: Viability, Challenges, and Current Approaches to Maintain Probiotic Viability.Biotechnology and bioengineering · 2026Review
- Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management.Journal of clinical medicine · 2026Review
- Probiotic Engraftment and Suppression of Canine Otitis Externa Pathogens by Probiotic Ear Drops.Veterinary dermatology · 2026Article
- The Bacterial Landscape of Facial Skin: From Homeostasis to Skin Conditions.Dermatology and therapy · 2026Review
- Review
- Multi-Kingdom Synergy ofLife (Basel, Switzerland) · 2026Review
- A Global Delphi Consensus on Acne and the Microbiome: Integrating International Expertise for Innovative Prevention and Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae.Microbial cell factories · 2026Review
- The probiotic Lactiplantibacillus plantarum ATCC10241 inhibits wound-associated pathogens through the secretion of organic acids.Scientific reports · 2026Article
- Pangenome-based design of strain-specific primers enables precise monitoring of bacteria in human microbiome intervention trials.Scientific reports · 2026Article
- Neuropeptides neurotensin and substance P accelerate diabetic wound healing by modulating immunity and the skin microbiome.Scientific reports · 2026Article
- Lactobacilli biology, applications and host interactions.Nature reviews. Microbiology · 2026Review
- Microbiome-Derived Indole-3-Lactic Acid AttenuatesInternational journal of molecular sciences · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tailored skin microbiome modulation approaches with probiotics are highly challenging. Here, we show that lactobacilli are underestimated members of the skin microbiota. We select specific strains of nomadic lactobacilli for their functional applicability on the skin and capacity to inhibit growth and inflammation by skin pathobionts. The strains are formulated as microcapsules for topical formulations and tested in patients with mild-to-moderate acne. The selected lactobacilli are able to reduce inflammatory lesions in a pilot and placebo-controlled study. Daily application for 8 weeks is associated with an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.