Evidence map›Paper›PMID 35243395›Full record

ArticleEuropean urology open science2022

Red Blood Cell Distribution Width Is Associated with All-cause Mortality but Not Adverse Cancer-specific Outcomes in Men with Clinically Localized Prostate Cancer Treated with Radical Prostatectomy: Findings Based on a Multicenter Shared Equal Access Regional Cancer Hospital Registry.

Hazem Orabi, Lauren Howard, Christopher L Amling, William J Aronson, Matthew R Cooperberg, Christopher J Kane, Martha K Terris, Zachary Klaassen, Jessica L Janes, Stephen J Freedland and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European urology open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Clinicopathologic Characterization of Prostatic Cancer in Dogs.Animals : an open access journal from MDPI · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hazem OrabiDivision of Urology, Department of Surgery, Duke University, Durham, NC, USA.
Lauren HowardUrology Section, Department of Surgery, Veterans Affairs Medical Center, Durham, NC, USA.
Christopher L AmlingDepartment of Urology, Oregon Health & Science University, Veterans Affairs Medical Center, Portland, OR, USA.
William J AronsonDepartment of Urology, University of California at Los Angeles Medical Center, Veterans Affairs Medical Center, Los Angeles, CA, USA.
Matthew R CooperbergDepartments of Urology and Epidemiology & Biostatistics, University of California, Veterans Affairs Medical Centers, San Francisco, CA, USA.
Christopher J KaneDepartment of Urology, University of California at San Diego Medical Center, Veterans Affairs Medical Center, San Diego, CA, USA.
Martha K TerrisUrology Section, Department of Surgery, Veterans Affairs Medical Centers, Augusta, GA, USA.
Zachary KlaassenDepartment of Surgery, Section of Urology, Augusta University - Medical College of Georgia, Augusta, GA, USA.
Jessica L JanesUrology Section, Department of Surgery, Veterans Affairs Medical Center, Durham, NC, USA.
Stephen J FreedlandUrology Section, Department of Surgery, Veterans Affairs Medical Center, Durham, NC, USA.
Thomas J PolascikDivision of Urology, Department of Surgery, Duke University, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent reports with a small number of patients showed an association of red blood cell distribution width (RDW) with prostate cancer (PCa) progression.

objectiveTo investigate whether preoperative RDW can serve as a prognostic marker in patients with PCa undergoing radical prostatectomy (RP) in a large, equal access, and diverse patient cohort. DESIGN SETTING AND

participantsData were retrospectively collected on 4756 men treated with RP at eight Veteran Affairs medical centers within the Shared Equal Access Regional Cancer Hospital (SEARCH) database from 1999 through 2017. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Biochemical recurrence (BCR) was the primary outcome, while metastasis, all-cause mortality (ACM), and prostate cancer-specific mortality (PCSM) were secondary outcomes. RESULTS AND LIMITATIONS: The mean (standard deviation) age was 62 yr (6.1), and 1589 (33%) men were black. The median (interquartile range) follow-up was 82 mo (46-127). Preoperative RDW either as a continuous variable or when stratified by quartiles was not associated with BCR. Likewise, preoperative RDW was not associated with metastases or PCSM. However, higher RDW was significantly associated with higher ACM, both as a continuous variable (

conclusionsPreoperative RDW was not associated with PCa outcomes in men treated with RP but was associated with ACM. While RDW may be a biomarker of overall health, it is not a biomarker for PCa outcomes. These results emphasize the importance of diverse, larger sized studies in genitourinary cancer research. PATIENT SUMMARY: Prostate cancer includes a wide spectrum of diseases with different genetic, pathological, and oncological behaviors. Red blood cell distribution width is helpful in predicting the overall survival for a localized prostate cancer patient, and hence, it can help inform personalized treatment decisions and operative care.

Indexed as

OutcomesProstate cancerRadical prostatectomyRed blood cell distribution widthSurvival

Identifiers

PMID35243395
PMCPMC8883186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.