Evidence map›Paper›PMID 35243393›Full record

ArticleEuropean urology open science2022

Multidrug-resistant Uro-associated

Catherine Mowbray, Aaron Tan, Maxime Vallée, Holly Fisher, Thomas Chadwick, Catherine Brennand, Katherine E Walton, Robert S Pickard, Christopher Harding, Phillip D Aldridge and 1 more

Open access · goldAbstract read
In one paragraph

Article in European urology open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Trimethoprim resistance inJournal of medical microbiology · 2025
    Article
  4. Article
  5. Article
  6. ISMicrobial genomics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Catherine MowbrayBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Aaron TanBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Maxime ValléeBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Holly FisherPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Thomas ChadwickPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Catherine BrennandNewcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.
Katherine E WaltonDepartment of Microbiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Robert S PickardTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Christopher HardingTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Phillip D AldridgeBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Judith HallBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe AnTIC trial linked continuous low-dose antibiotic prophylaxis treatments to a lower incidence of symptomatic urinary tract infections (UTIs) among individuals performing clean intermittent self-catheterisation (CISC).

objectiveTo explore potential mechanisms underlying the protective effects of low-dose antibiotic prophylaxis treatments, blood and urine samples and uro-associated DESIGN SETTING AND

participantsBlood samples ( OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: RESULTS AND LIMITATIONS: Urine samples from CISC users, irrespective of antibiotic treatment regimens, were associated with robust urothelial innate responses. No links were identified between

conclusionsAntibiotic treatments did not impact urogenital responses to infection in CISC users. Host genetics in terms of PATIENT SUMMARY: Our findings show that the natural urogenital defences of clean intermittent self-catheterisation (CISC) users were not impacted by antibiotic treatments. For some CISC users, prophylaxis with low-dose antibiotics selected for a stable, predominantly,

Indexed as

AntibioticsContinuous intermittent single-use catheterisationEscherichia coliInnate immunityLower urinary tract infectionMultidrug resistanceProphylaxisTLR genotypeTLR genotype, Toll-like Receptor genotype

Identifiers

PMID35243393
PMCPMC8883198
OpenAlexW4210305785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.