ReviewEuropean urology open science2022
Role of Prophylactic Antibiotics in Transperineal Prostate Biopsy: A Systematic Review and Meta-analysis.
Review in European urology open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06359964 (Infective Complications in Transperineal Prostate Biopsy Without Antibiotic Prophylaxis), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Infective Complications in Transperineal Prostate Biopsy Without Antibiotic Prophylaxis: A Prospective Cohort Study
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Infectious complications following transperineal prostate biopsy with or without periprocedural antibiotic prophylaxis-a systematic review including meta-analysis of all comparative studies.Prostate cancer and prostatic diseases · 2026Pooled it
- [Prostate biopsy-infection prophylaxis and patient preparation].Urologie (Heidelberg, Germany) · 2023Pooled it
- Trial
- Pain and patient-reported experience after freehand transperineal prostate biopsy under local anaesthesia.BJUI compass · 2026Article
- Successes and challenges in developing a magnetic resonance imaging-transrectal ultrasound machine fusion prostate biopsy service.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Review
- Superior cancer detection with transperineal biopsy in patients with an elevated prostate-specific antigen level and a PI-RADS score of 3-4: A retrospective cohort study.Oncology letters · 2026Article
- Haemorrhagic risk of transperineal ultrasound-guided prostate biopsy performed under continued antithrombotic therapy.BJUI compass · 2026Article
- Transperineal Versus Transrectal Prostate Biopsy in the MRI-Targeted Era: A Contemporary Narrative Review.Biomedicines · 2026Review
- Perioperative antibiotic prophylaxis, prostate size and transperineal prostate biopsy.BJUI compass · 2026Article
- Infection rates of trans-perineal versus trans-rectal prostate biopsy: A Middle Eastern tertiary center experience-Time for a change?Arab journal of urology · 2026Article
- [Efficiency and safety of transperineal prostate biopsy with a single access point].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Safety of Single-Dose Oral Cefaclor Prophylaxis in Transperineal Prostate Biopsy.Research and reports in urology · 2026Article
- Accuracy and safety of in-office transperineal freehand cognitive fusion prostate biopsy under local anaesthesia without antibiotic prophylaxis.Scientific reports · 2025Article
- Antibiotic prophylaxis for transperineal prostate biopsy.The Cochrane database of systematic reviews · 2025Article
- Article
- Reassessing the evidence on transperineal prostate biopsy without antibiotic prophylaxis.World journal of urology · 2025Article
- Retrospective, single center evaluation of transperineal prostate biopsy omitting antibiotic prophylaxis and omitting periinterventional screening for bacteriuria.World journal of urology · 2025Article
- Use versus nonuse of antimicrobial prophylaxis prior to transperineal prostate biopsy: a propensity score-matched analysis.Prostate international · 2025Article
- Transperineal prostate biopsy with freehand technique under local anaesthetic: A systematic review and meta-analysis.BJUI compass · 2025Review
- Antibiotic prophylaxis may be still required among transperineal prostate biopsies of diabetics: a cohort study.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextTransperineal prostate biopsy is associated with a significantly lower risk of infectious complications than the transrectal approach. In fact, the risk of infectious complications with transperineal prostate biopsy is so low that the utility of administering periprocedural antibiotics with this procedure has come under question.
objectiveTo perform a systematic review and meta-analysis to assess for differences in the rates of infectious complications (septic, nonseptic, and overall) after performing transperineal prostate biopsy with and without the administration of periprocedural antibiotic prophylaxis. EVIDENCE ACQUISITION: Three electronic databases (PubMed, Embase, and MEDLINE) were searched, and studies were included if they included patients who underwent transperineal prostate biopsy, were published after January 2000, included information on periprocedural antibiotic administration, and reported postbiopsy complications. Preferred Reporting Items for Systematic Reviews and Meta-analyses and Agency for Healthcare Research and Quality guidelines were utilized. EVIDENCE SYNTHESIS: A total of 106 unique studies describing 112 cohorts of patients were identified, of which 98 (37 805 men) received antibiotic prophylaxis and 14 (4772 men) did not receive it. All patients were included in the analysis of septic complications. In total, there were 19/37 805 (0.05%) episodes of sepsis in the group of men who received antibiotics, which was similar to the no antibiotic group with 4/4772 (0.08%) episodes (
conclusionsThe likelihood of septic infections after transperineal prostate biopsy is low with and without antibiotic prophylaxis. The omission of periprocedural antibiotics with this procedure stands to benefit patients by avoiding potential drug reactions. Furthermore, this practice is in line with calls throughout the medical community for improved antibiotic stewardship. PATIENT SUMMARY: In a large systematic review and meta-analysis, we evaluated infectious complications after transperineal prostate biopsy with or without the administration of prophylactic antibiotics. We conclude that prophylactic antibiotics do not decrease the rate of postbiopsy sepsis but may have a small benefit in terms of preventing less serious infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.