Evidence map›Paper›PMID 35243343›Full record

ArticleBrain communications2022

Radiological identification of temporal lobe epilepsy using artificial intelligence: a feasibility study.

Ezequiel Gleichgerrcht, Brent Munsell, Simon S Keller, Daniel L Drane, Jens H Jensen, M Vittoria Spampinato, Nigel P Pedersen, Bernd Weber, Ruben Kuzniecky, Carrie McDonald and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. AI in epilepsy neuroimaging.Current opinion in neurology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Ezequiel GleichgerrchtDepartment of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID https://orcid.org/0000-0002-4212-4146
Brent MunsellDepartment of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.ORCID https://orcid.org/0000-0001-5247-9795
Daniel L DraneDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.
Jens H JensenCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, USA.
M Vittoria SpampinatoDepartment of Radiology, Medical University of South Carolina, Charleston, SC 29425, USA.
Nigel P PedersenDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0002-8494-0635
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn 53113, Germany.
Ruben KuznieckyDepartment of Neurology, Hofstra University/Northwell, New York, NY 10075, USA.
Carrie McDonaldDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Leonardo BonilhaDepartment of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.
Medical University of South Carolina · USEmory University · USHofstra University · USUniversity of Bonn · DEUniversity of California San Diego · USUniversity of Liverpool · GBUniversity of North Carolina at Chapel Hill · US

Funding

National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Lifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8M
Predicting Epilepsy Surgery Outcomes Using Neural Network ArchitectureR01NS110347 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BONILHA, LEONARDO F, DRANE, DANIEL L · 2019 to 2023
$3.6M
Prediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy studyR21NS107739 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONILHA, LEONARDO F, MCDONALD, CARRIE R · 2019 to 2019
$444k
Medical Research Council MR/S00355X/1NIMH NIH HHS R01 MH118514NINDS NIH HHS L30 NS080215NINDS NIH HHS R01 NS088748NINDS NIH HHS R01 NS110347NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739
6 · The paper itself

Abstract

Temporal lobe epilepsy is associated with MRI findings reflecting underlying mesial temporal sclerosis. Identifying these MRI features is critical for the diagnosis and management of temporal lobe epilepsy. To date, this process relies on visual assessment by highly trained human experts (e.g. neuroradiologists, epileptologists). Artificial intelligence is increasingly recognized as a promising aid in the radiological evaluation of neurological diseases, yet its applications in temporal lobe epilepsy have been limited. Here, we applied a convolutional neural network to assess the classification accuracy of temporal lobe epilepsy based on structural MRI. We demonstrate that convoluted neural networks can achieve high accuracy in the identification of unilateral temporal lobe epilepsy cases even when the MRI had been originally interpreted as normal by experts. We show that accuracy can be potentiated by employing smoothed grey matter maps and a direct acyclic graphs approach. We further discuss the foundations for the development of computer-aided tools to assist with the diagnosis of epilepsy.

Indexed as

artificial intelligenceconvoluted neural networkstructural neuroimagingtemporal lobe epilepsy

Identifiers

PMID35243343
PMCPMC8887904
OpenAlexW4206587798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.