ArticleEClinicalMedicine2022
Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Informing the Development of Tailored Antenatal Care Services for Pregnant Adolescents: A Systematic Review and Stakeholder Survey.Nutrients · 2026Pooled it
- Article
- Well-care visit attendance among children of adolescent mothers in South Africa: a theory-informed mixed-methods study.BMC public health · 2026Article
- Maternal and Neonatal Outcomes in Very Young Adolescent Pregnancies: A Single-Centre Retrospective Observational Study in Brașov, Romania.Healthcare (Basel, Switzerland) · 2026Article
- Article
- Observational
- The effects of government-led cash transfer programmes on behavioural and health determinants of mortality: a difference-in-differences study.Lancet (London, England) · 2025Article
- Maternal mortality ratios in Southeast Asia (1990-2021): trends, disparities, and projections through 2050 based on the global burden of disease 2021, with reference to SDG 3.1.BMC pregnancy and childbirth · 2025Article
- Maternal age and parity influences on health outcomes: a multivariable regression analysis of mothers and infants.BMC pregnancy and childbirth · 2025Article
- Influence on Consultation Behavior of Pregnant and Postpartum Women in Japan: Insights from a Nation-Wide Survey.Healthcare (Basel, Switzerland) · 2025Article
- Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health.Medicina (Kaunas, Lithuania) · 2025Review
- Estimated effect of teenage pregnancy on adverse birth outcome in Sub-Saharan African countries: propensity score matching analysis of recent demographic and health survey data.BMC pregnancy and childbirth · 2025Article
- How do gender transformative interventions reduce adolescent pregnancy in low- and middle-income countries: a realist synthesis.Journal of global health · 2025Review
- Socio-structural influences on unintended pregnancy among girls aged 15-17 years in Papua New Guinea.BMJ global health · 2025Article
- Prevalence and determinants of adverse pregnancy outcomes among teenage mothers in the Limbe Health District of Cameroon.The Pan African medical journal · 2025Article
- Association between adolescent pregnancy and infant mortality: a population-based study.Frontiers in pediatrics · 2025Article
- Adverse obstetric and perinatal outcomes among Palestinian adolescent mothers in the West Bank: a retrospective cohort study.Frontiers in global women's health · 2025Article
- Article
- Mechanisms behind gender transformative approaches targeting adolescent pregnancy in low- and middle-income countries: a realist synthesis protocol.Systematic reviews · 2024Article
- Young men's everyday life experiences with contraception and unintended pregnancy in Papua New Guinea.PLOS global public health · 2024Article
Corrections and comments
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Authors and funding
27 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundAdolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, nutrition, and pregnancy and birth outcomes for adolescent mothers (10-19 years) compared to older mothers in low and middle-income countries.
methodsThis study was conducted between March 16, 2018 and May 25, 2021. Data were obtained from 20 randomised controlled trials of micronutrient supplementation in pregnancy. Stratified analyses were conducted by age (10-14 years, 15-17 years, 18-19 years, 20-29 years, 30-39 years, 40+ years) and geographical region (Africa, Asia). Crude and confounder-adjusted means, prevalence and relative risks of pregnancy, nutrition and birth outcomes were estimated using multivariable linear and log-binomial regression models with 95% confidence intervals.
findingsAdolescent mothers comprised 31.6% of our data. Preterm birth, small-for-gestational age (SGA), low birthweight (LBW) and newborn mortality followed a U-shaped trend in which prevalence was highest among the youngest mothers (10-14 years) and then reduced gradually, but increased again for older mothers (40+ years). When compared to mothers aged 20-29 years, there was a 23% increased risk of preterm birth, a 60% increased risk of perinatal mortality, a 63% increased risk of neonatal mortality, a 28% increased risk of LBW, and a 22% increased risk of SGA among mothers 10-14 years. Mothers 40+ years experienced a 22% increased risk of preterm birth and a 103% increased risk of stillbirth when compared to the 20-29 year group.
interpretationThe youngest and oldest mothers suffer most from adverse pregnancy and birth outcomes. Policy and programming agendas should consider both biological and socioeconomic/environmental factors when targeting these populations.
fundingBill and Melinda Gates Foundation (Grant No: OP1137750).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.