Evidence map›Paper›PMID 35243258›Full record

ArticleiScience2022

Horizontal mtDNA transfer between cells is common during mouse development.

Nuria Marti Gutierrez, Aleksei Mikhalchenko, Hong Ma, Amy Koski, Ying Li, Crystal Van Dyken, Rebecca Tippner-Hedges, David Yoon, Dan Liang, Tomonari Hayama and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Nuria Marti GutierrezCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Aleksei MikhalchenkoCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Hong MaCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Amy KoskiCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Ying LiCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Crystal Van DykenCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Rebecca Tippner-HedgesCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
David YoonCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Dan LiangCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Tomonari HayamaCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
David BattagliaCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Eunju KangStem Cell Center & Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Yeonmi LeeStem Cell Center & Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
Anthony Paul BarnesKnight Cardiovascular Institute, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Paula AmatoCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Shoukhrat MitalipovCenter for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR 97239, USA.
Oregon Health & Science University · USUlsan College · KR

Funding

Horizontal mtDNA ExchangeR01AG062459 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2019 to 2023
$2.8M
NIA NIH HHS R01 AG062459
6 · The paper itself

Abstract

Cells transmit their genomes vertically to daughter cells during cell divisions. Here, we demonstrate the occurrence and extent of horizontal mitochondrial (mt)DNA acquisition between cells that are not in a parent-offspring relationship. Extensive single-cell sequencing from various tissues and organs of adult chimeric mice composed of cells carrying distinct mtDNA haplotypes showed that a substantial fraction of individual cardiomyocytes, neurons, glia, intestinal, and spleen cells captured donor mtDNA at high levels. In addition, chimeras composed of cells with wild-type and mutant mtDNA exhibited increased trafficking of wild-type mtDNA to mutant cells, suggesting that horizontal mtDNA transfer may be a compensatory mechanism to restore compromised mitochondrial function. These findings establish the groundwork for further investigations to identify mtDNA donor cells and mechanisms of transfer that could be critical to the development of novel gene therapies.

Indexed as

Cell biologyDevelopmental biologyMolecular biology

Identifiers

PMID35243258
PMCPMC8873606
OpenAlexW4210983620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.