ArticleiScience2022
Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk.Genome medicine · 2026Article
- Redox control at the ER-mitochondria interface in kidney transplantation: MAM-centered stress signaling and translational organoid platforms.Redox biology · 2026Review
- Applications of Stem Cells and Modern Toxicological Analytical Methods in the Toxicity of Microplastics.Toxics · 2026Review
- Recent advances and expanding applications of organoid models in unveiling drug ADME profiles.Journal of pharmaceutical analysis · 2026Review
- In vitro modeling of renal injury-induced cardiac effects using human iPSC-derived organoids.Cell communication and signaling : CCS · 2026Article
- Organoids in drug development: from predictive models to regulatory integration.Drug discovery today · 2026Review
- Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation.Advanced healthcare materials · 2026Review
- Induction of Nephron-Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids.Advanced healthcare materials · 2025Article
- Urine-derived stem cells display homing, incorporation, and regeneration in human organoid and mouse models of acute kidney injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Impact of nephrotoxins and oxidants on survival and transport function of hiPSC-derived renal proximal tubular cells.Archives of toxicology · 2025Article
- Toxicity Testing Using Organoids Made from Human-Induced Pluripotent Stem Cells Engineered to Report Oxidative Stress.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Advancements in theFrontiers in toxicology · 2025Review
- Optimizing miRNA transfection for screening in precision cut lung slices.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Progress and breakthroughs in human kidney organoid research.Biochemistry and biophysics reports · 2024Review
- Kidney organoids: steps towards better organization and function.Biochemical Society transactions · 2024Review
- Kidney Disease Modeling with Organoids and Organs-on-Chips.Annual review of biomedical engineering · 2024Review
- Article
- Sensitivity of Human Induced Pluripotent Stem Cells and Thereof Differentiated Kidney Proximal Tubular Cells towards Selected Nephrotoxins.International journal of molecular sciences · 2023Article
- Ascorbate protects human kidney organoids from damage induced by cell-free hemoglobin.Disease models & mechanisms · 2023Article
- Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models.Trends in pharmacological sciences · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Advances in regenerative medicine have led to the construction of many types of organoids, which reproduce important aspects of endogenous organs but may be limited or disorganized in nature. While their usefulness for restoring function remains unclear, they have undoubted usefulness in research, diagnostics, and toxicology. In toxicology, there is an urgent need for better models for human kidneys. We used human iPS-cell (hiPSC)-derived renal organoids to identify HMOX1 as a useful marker of toxic stress via the oxidative stress pathway, and then constructed an HMOX1 reporter in hiPSCs. We used two forms of hiPSC-derived HMOX1-reporter renal organoids to probe their ability to detect nephrotoxicants in a panel of blind-coded compounds. Our results highlight the potential usefulness, and some limitations, of HMOX1-reporter renal organoids as screening tools. The results may guide development of similar stress-reporting organoid assays for other stem-cell-derived organs and tissues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.