Evidence map›Paper›PMID 35243180›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways.

Edwin N Aroke, Pamela Jackson, Lingsong Meng, Zhiguang Huo, Demario S Overstreet, Terence M Penn, Tammie L Quinn, Yenisel Cruz-Almeida, Burel R Goodin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Edwin N ArokeSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Pamela JacksonSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Lingsong MengDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Zhiguang HuoDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Demario S OverstreetDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Terence M PennDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Tammie L QuinnDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yenisel Cruz-AlmeidaCollege of Dentistry, University of Florida, Gainesville, FL, USA.
Burel R GoodinDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USUniversity of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
UAB Health Services Research (HSR) Training ProgramT32HS013852 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, MUGAVERO, MICHAEL J · 2003 to 2024
$8.0M
Racial and Socioeconomic Differences in Chronic Low Back PainR01MD010441 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOODIN, BUREL R., SORGE, ROBERT · 2017 to 2021
$2.6M
Epigenomic and Gene Expression Signatures of Racial Differences in Chronic Low Back PainR01AR079178 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AROKE, EDWIN NGOMUEH · 2021 to 2024
$1.6M
AHRQ HHS T32 HS013852NIAMS NIH HHS R01 AR079178NIA NIH HHS P30 AG028740NIMHD NIH HHS R01 MD010441
6 · The paper itself

Abstract

Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP. PURPOSE: To determine the relationship between DNAm levels and racial group differences in adults with cLBP. Our study's secondary purpose was to perform a race-stratified comparison of adults with cLBP and pain-free controls and identify functional genomic pathways enriched by annotated differentially methylated genes. PATIENTS AND

methodsWe recruited 49 NHBs and 49 NHWs (49 cLBP and 49 pain-free controls, PFCs), analyzed DNAm from whole blood using reduced representation bisulfite sequencing, and identified enriched genomic pathways.

resultsAmong participants with cLBP, we identified 2873 differentially methylated loci (DML; methylation differences of at least 10% and p < 0.0001), many of which were annotated to genes of importance to pain pathology. These DMLs significantly enriched pathways to involved in nociception/pain processing (

conclusionEven though an individual's self-identified race is a social construct, not a biological variable, racism associated with that classification affects virtually every aspect of life, including disease risk. DNAm induced alterations in stress signaling pathways may explain worse pain outcomes in NHBs.

Indexed as

Chronic low back paincLBP, Chronic low back painDML, DIfferentially methylated lociDNAm, DNA methylationDNA methylationEpigeneticsNHB, Non-Hispanic BlackNHW, Non-Hispanic WhiteNon-specific chronic low back painPain mechanismsPFC, Pain free controlRacial pain disparitiesRRBSRRBS, Reduced representation bisulfite sequencing

Identifiers

PMID35243180
PMCPMC8885563
OpenAlexW4214601818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.