Evidence map›Paper›PMID 35243162›Full record

ArticleAmerican journal of ophthalmology case reports2022

Metastatic neuroendocrine tumors mimicking as primary ocular disease.

Alice Shen, Arezu Haghighi, Tom Liang, On-Tat Lee, William Gange, Charles DeBoer, Mashal Akhter, Maria Sibug Saber, Vivek R Patel, Jesse L Berry and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alice ShenLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Arezu HaghighiLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Tom LiangLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
On-Tat LeeLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
William GangeLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Charles DeBoerLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Mashal AkhterLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Maria Sibug SaberLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Vivek R PatelLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Jesse L BerryLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
Kimberly Kinga GokoffskiLos Angeles County + University of Southern California Medical Center, Department of Ophthalmology, 2051 Marengo St, Los Angeles, CA, 90033, USA.
University of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report two cases of metastatic neuroendocrine tumors masquerading as primary ocular disease. OBSERVATIONS: Case 1 is a 38-year-old man who was referred with subacute onset diplopia and fluctuating ptosis suggestive of myasthenia gravis. Case 2 is a 21-year-old man who presented with blurry vision and was found to have a pigmented ciliary body mass and retinal detachment suggestive of uveal melanoma. Both patients were ultimately diagnosed with metastatic neuroendocrine tumors. CONCLUSIONS AND IMPORTANCE: Neuroendocrine tumors, though rare and infrequently metastatic to the eye and orbit, can initially present with ocular signs. A broad differential and careful consideration of ocular and systemic symptoms are critical in such challenging cases.

Indexed as

Ciliary body tumorIntraocular metastasisNeuroendocrine tumorOrbital metastasis

Identifiers

PMID35243162
PMCPMC8858882
OpenAlexW4213339008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.