Evidence map›Paper›PMID 35243129›Full record

ArticleAmerican journal of ophthalmology case reports2022

Ocular findings associated with FADD deficiency resemble familial exudative vitreoretinopathy.

Elana Meer, Federica Solanes, Lisa Kohn, Caroline Y Kuo, Derek A Wong, Stacy Pineles, Irena Tsui

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Infections in Disorders of Immune Regulation.Pathogens (Basel, Switzerland) · 2024
    Review
  3. Review
  4. FADD as a key molecular player in cancer progression.Molecular medicine (Cambridge, Mass.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Elana MeerUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Federica SolanesStein Eye Institute, Department of Ophthalmology, UCLA, USA.
Lisa KohnPediatric Allergy and Immunology, Department of Pediatrics, UCLA, USA.
Caroline Y KuoPediatric Allergy and Immunology, Department of Pediatrics, UCLA, USA.
Derek A WongGenetics, Department of Pediatrics, UCLA, USA.
Stacy PinelesStein Eye Institute, Department of Ophthalmology, UCLA, USA.
Irena TsuiStein Eye Institute, Department of Ophthalmology, UCLA, USA.
Pediatrics and Genetics · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe report the first known case of eye findings associated with a Fas-associated protein with death domain (FADD) gene mutation, an exceedingly rare entity. OBSERVATIONS: A 7-year-old boy was referred for decreased vision and eye examination revealed cystoid macular edema and peripheral retinal ischemia in both eyes and progression to tractional retinal detachment in the right eye. CONCLUSIONS AND IMPORTANCE: This case suggests that baseline and annual ophthalmic screening may be beneficial in individuals with FADD mutations. However, greater documentation of cases may be necessary before deriving a clear interval screening recommendation.

Indexed as

Cystoid macular edemaFamilial exudative vitreoretinopathyFas-associated protein with death domain deficiencyRetinal ischemiaRetinal neovascularizationTractional retinal detachment

Identifiers

PMID35243129
PMCPMC8859737
OpenAlexW4210357526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.