Evidence map›Paper›PMID 35243040›Full record

ArticlePhysics and imaging in radiation oncology2022

Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom.

Iosif Papoutsis, Ingerid Skjei Knudtsen, Erlend Peter Skaug Sande, Bernt Louni Rekstad, Michel Öllers, Wouter van Elmpt, Marius Røthe Arnesen, Eirik Malinen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Iosif PapoutsisDepartment of Physics, University of Oslo, P.O. Box 1048 Blindern, N-0316 Oslo, Norway.
Ingerid Skjei KnudtsenDepartment of Medical Physics, Oslo University Hospital, P.O. Box 4953 Nydalen, N-0424 Oslo, Norway.
Erlend Peter Skaug SandeDepartment of Medical Physics, Oslo University Hospital, P.O. Box 4953 Nydalen, N-0424 Oslo, Norway.
Bernt Louni RekstadDepartment of Medical Physics, Oslo University Hospital, P.O. Box 4953 Nydalen, N-0424 Oslo, Norway.
Michel ÖllersDepartment of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands.
Wouter van ElmptDepartment of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, the Netherlands.
Marius Røthe ArnesenDepartment of Medical Physics, Oslo University Hospital, P.O. Box 4953 Nydalen, N-0424 Oslo, Norway.
Eirik MalinenDepartment of Physics, University of Oslo, P.O. Box 1048 Blindern, N-0316 Oslo, Norway.
Oslo University Hospital · NOMaastro Clinic · NLUniversity Medical Center · USUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of MATERIALS AND

methodsA linear dose prescription based on

resultsA pointwise comparison between GTV doses from prescription, treatment plan calculation and VMAT delivery showed high correspondence, with a mean and maximum dose difference of <0.1 Gy and 0.3 Gy, respectively. No difference was found in dosimetric accuracy between scheme A and B. The misalignment caused deviations up to 1 Gy between prescription and delivery.

conclusionDPBN can be delivered with high accuracy, showing that the treatment may be applied correctly from a dosimetric perspective. Still, misalignment may cause considerable dosimetric erros, indicating the need for patient immobilization and monitoring.

Indexed as

Dose painting by numbersDose painting by numbers, DPBNElectron paramagnetic resonanceElectron paramagnetic resonance, EPRImaging for radiotherapyRadiotherapyVolumetric modulated arc radiotherapy, VMATVolumetric modulated arc therapy

Identifiers

PMID35243040
PMCPMC8885607
OpenAlexW4214499003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.