ArticlePhysics and imaging in radiation oncology2022
Inter- and intrafraction motion assessment and accumulated dose quantification of upper gastrointestinal organs during magnetic resonance-guided ablative radiation therapy of pancreas patients.
Article in Physics and imaging in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Feasibility of dose accumulation for assessing treatment-related side effects in MR-guided abdominal SABR: A single-institution study.Clinical and translational radiation oncology · 2026Article
- Assessment of planning organ at risk volume margins in non-adaptive pancreatic stereotactic body radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Impact of daily volumetric imaging on target tracking without fiducial markers during robotic treatment of pancreas.Physics in medicine and biology · 2026Article
- Optical Flow-Guided Analysis of Intrafractional Anatomical Variations in Pancreatic Tumors and Organs at Risk During Magnetic Resonance-Guided Adaptive Radiation Therapy Under Abdominal Compression.Advances in radiation oncology · 2026Article
- Modality-agnostic, patient-specific digital twins modeling temporally varying digestive motion.Physics in medicine and biology · 2026Article
- Article
- Stereotactic body radiation therapy for inoperable non-metastasized pancreatic adenocarcinoma: a randomised phase II study (TORPEDO).BMC cancer · 2025Article
- Workflow to detect exceeded dose constraints in pancreatic stereotactic body irradiation after intrafraction motion during magnetic resonance-guided adaptive radiotherapy using a deep learning-refined contour propagation tool.Physics and imaging in radiation oncology · 2025Article
- Imaging, automation and workflow challenges for online adaptive proton therapy.Physics and imaging in radiation oncology · 2025Article
- Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Review
- A vessel bifurcation landmark pair dataset for abdominal CT deformable image registration (DIR) validation.Medical physics · 2025Article
- Intrafraction motion and impact of margin reduction for MR-Linac online adaptive radiotherapy for pancreatic cancer treatments.Journal of medical radiation sciences · 2025Article
- Data Science Opportunities To Improve Radiotherapy Planning and Clinical Decision Making.Seminars in radiation oncology · 2024Review
- Comparison of online adaptive and non-adaptive magnetic resonance image-guided radiation therapy in prostate cancer using dose accumulation.Physics and imaging in radiation oncology · 2024Article
- Tools and recommendations for commissioning and quality assurance of deformable image registration in radiotherapy.Physics and imaging in radiation oncology · 2024Review
- A multi-institutional comparison of retrospective deformable dose accumulation for online adaptive magnetic resonance-guided radiotherapy.Physics and imaging in radiation oncology · 2024Article
- Treatment planning evaluation and experimental validation of the magnetic resonance-based intrafraction drift correction.Physics and imaging in radiation oncology · 2024Article
- The role of 4D particle therapy in daily patient care and research.Physics and imaging in radiation oncology · 2024Article
- Artificial intelligence-based automated segmentation and radiotherapy dose mapping for thoracic normal tissues.Physics and imaging in radiation oncology · 2024Article
- Predicting cervical cancer target motion using a multivariate regression model to enable patient selection for adaptive external beam radiotherapy.Physics and imaging in radiation oncology · 2024Article
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8 authors.
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Abstract
background and purposeStereotactic body radiation therapy (SBRT) of locally advanced pancreatic cancer (LAPC) is challenging due to significant motion of gastrointestinal (GI) organs. The goal of our study was to quantify inter and intrafraction deformations and dose accumulation of upper GI organs in LAPC patients. MATERIALS AND
methodsFive LAPC patients undergoing five-fraction magnetic resonance-guided radiation therapy (MRgRT) using abdominal compression and daily online plan adaptation to 50 Gy were analyzed. A pre-treatment, verification, and post-treatment MR imaging (MRI) for each of the five fractions (75 total) were used to calculate intra and interfraction motion. The MRIs were registered using Large Deformation Diffeomorphic Metric Mapping (LDDMM) deformable image registration (DIR) method and total dose delivered to stomach_duodenum, small bowel (SB) and large bowel (LB) were accumulated. Deformations were quantified using gradient magnitude and Jacobian integral of the Deformation Vector Fields (DVF). Registration DVFs were geometrically assessed using Dice and 95th percentile Hausdorff distance (HD95) between the deformed and physician's contours. Accumulated doses were then calculated from the DVFs.
resultsMedian Dice and HD95 were: Stomach_duodenum (0.9, 1.0 mm), SB (0.9, 3.6 mm), and LB (0.9, 2.0 mm). Median (max) interfraction deformation for stomach_duodenum, SB and LB was 6.4 (25.8) mm, 7.9 (40.5) mm and 7.6 (35.9) mm. Median intrafraction deformation was 5.5 (22.6) mm, 8.2 (37.8) mm and 7.2 (26.5) mm. Accumulated doses for two patients exceeded institutional constraints for stomach_duodenum, one of whom experienced Grade1 acute and late abdominal toxicity.
conclusionLDDMM method indicates feasibility to measure large GI motion and accumulate dose. Further validation on larger cohort will allow quantitative dose accumulation to more reliably optimize online MRgRT.
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