ArticleFrontiers in cardiovascular medicine2022
Clinical Phenotypes With Prognostic Implications in Pulmonary Embolism Patients With Syncope.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Thoracic muscle loss increases the use of mechanical ventilation in elderly patients with pulmonary embolism: constructing and validating a machine learning model on a two-center cohort.BMC geriatrics · 2026Article
- From Clusters to Outcomes: Machine Learning-Based Phenotyping in Intermediate-High-Risk Acute Pulmonary Embolism.Pulmonary circulation · 2026Article
- Syncope and In-Hospital Mortality in Pulmonary Embolism: Insights from 300 Patients.Life (Basel, Switzerland) · 2025Article
- Syncope in Pulmonary Thromboembolism: A Cross-Sectional Analysis of Risk Factors and the Prognostic Value of Syncope.Journal of clinical medicine · 2025Article
- Signs and symptoms of acute pulmonary embolism and their predictive value for all-cause hospital death in respect of severity of the disease, age, sex and body mass index: retrospective analysis of the Regional PE Registry (REPER).BMJ open respiratory research · 2023Article
- Seizure as the clinical presentation of massive pulmonary embolism: Case report and literature review.Frontiers in medicine · 2022Article
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Authors and funding
28 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere are conflicting data concerning the prognostic significance of syncope in acute pulmonary embolism (PE). This study aimed to investigate the impact of syncope on clinical outcomes of acute PE, and determine the clinical phenotypes of PE patients with syncope and their correlation with prognosis.
methodsIn the ongoing, national, multicenter, registry study, the China pUlmonary thromboembolism REgistry Study (CURES) enrolling consecutive patients with acute PE, patients with and without syncope were investigated. Principal component analysis (PCA) was performed using nine variables relevant to syncope and PE, including age, sex, body mass index, history of cardiovascular disease, recent surgery or trauma, malignancy, pulse, systolic blood pressure, and respiratory rate. Patient classification was performed using cluster analysis based on the PCA-transformed data. The clinical presentation, disease severity and outcomes were compared among the phenotypes.
resultsIn 7,438 patients with acute PE, 777 (10.4%) had syncope, with younger age, more females and higher body mass index. Patients with syncope had higher frequency of precordial pain, palpitation, and elevated cardiac biomarkers, as well as higher D-Dimer level. In the syncope group, more patients had right ventricular/left ventricular ratio > 0.9 in ultrasonic cardiogram and these patients had higher estimated pulmonary arterial systolic pressure compared with patients without syncope. As the initial antithrombotic treatment, more patients with syncope received systemic thrombolysis. Despite a higher prevalence of hemodynamic instability (OR 7.626, 95% CI 2.960-19.644,
conclusionSyncope was associated with hemodynamic instability and more application of thrombolysis, without increasing in-hospital deaths. Different clinical phenotypes existed in PE patients with syncope, which might be caused by various mechanisms and thus correlated with clinical outcomes.
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