Evidence map›Paper›PMID 35242775›Full record

ArticleFrontiers in medicine2022

The Expansion of Myeloid-Derived Suppressor Cells Correlates With the Severity of Pneumonia in Kidney Transplant Patients.

Bo Peng, Yulin Luo, Quan Zhuang, Junhui Li, Pengpeng Zhang, Min Yang, Yu Zhang, Gangcheng Kong, Ke Cheng, Yingzi Ming

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Proliferation of MDSCs may indicate a lowerParasite (Paris, France) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bo PengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Yulin LuoTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Quan ZhuangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Junhui LiTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Pengpeng ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Min YangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Yu ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Gangcheng KongTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Ke ChengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Yingzi MingTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.
National Health and Family Planning Commission · CNThird Xiangya Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPneumonia is one of the most frequent but serious infectious complications post kidney transplantation. Severe pneumonia induces sustained immunosuppression, but few parameters concerning immune status are used to assess the severity of pneumonia. Myeloid-derived suppressor cells (MDSCs) are induced under infection and have the strong immunosuppressive capacity, but the correlation between MDSCs and pneumonia in kidney transplant recipients (KTRs) is unknown.

methodsPeripheral blood MDSCs were longitudinally detected in 58 KTRs diagnosed with pneumonia using flow cytometry and in 29 stable KTRs as a control. The effectors of MDSCs were detected in the plasma. Spearman's rank correlation analysis was performed to determine the correlation between MDSCs and the severity of pneumonia as well as lymphopenia.

resultsThe frequency of MDSCs and effectors, including arginase-1, S100A8/A9, and S100A12, were significantly increased in the pneumonia group compared with the stable group. CD11b

conclusionsMDSCs and G-MDSCs were persistently increased in KTRs with pneumonia. G-MDSCs were correlated with the severity of pneumonia and could thus be an indicator concerning immune status for assessing pneumonia severity.

Indexed as

immune monitoringimmunosuppressionkidney transplantationmyeloid-derived suppressor cells (MDSCs)pneumonia

Identifiers

PMID35242775
PMCPMC8885803
OpenAlexW4212886638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.