ArticleTranslational andrology and urology2022
Rapid impact of COVID-19 infection on semen quality: a case report.
Article in Translational andrology and urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- A comparative study of the effects of the COVID-19 pandemic on semen quality based on a nationwide relaxation of COVID-19 restrictions in China at the end of 2022.Translational andrology and urology · 2025Article
- CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.Endocrine · 2024Article
- The temporary impact of COVID-19 on semen deoxyribonucleic acid fragmentation.Central European journal of urology · 2024Article
- Persistent oligonecrozoospermia after asymptomatic SARS-CoV-2 infection. A case report and literature review.Heliyon · 2023Article
- SARS-CoV-2 and male infertility: from short- to long-term impacts.Journal of endocrinological investigation · 2023Review
- COVID-19 and Male Infertility: Is There a Role for Antioxidants?Antioxidants (Basel, Switzerland) · 2023Review
- SARS-CoV-2 Structural Proteins Modulated Blood-Testis Barrier-Related Proteins through Autophagy in the Primary Sertoli Cells.Viruses · 2023Article
- Review
- Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system.Frontiers in physiology · 2023Article
- COVID-19 associates with semen inflammation and sperm quality impairment that reverses in the short term after disease recovery.Frontiers in physiology · 2023Article
- The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review.Basic and clinical andrology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A unique opportunity to conduct a longitudinal analysis of semen quality in a male subject immediately before, during and after COVID-19 infection, has revealed new insights into the impact of this virus on male reproductive function. A moderate COVID infection that did not require hospitalization resulted in a state of azoospermia that persisted for 4 weeks. Given that the duration of spermatogenesis and epididymal sperm maturation in the human is 78 days, we calculate that a viral attack on the germ line was initiated at or before the patient was symptomatic and may have been signalled by a sudden reduction in sperm count and motility, several weeks earlier. Before the virus had been fully cleared, reinitiation of spermatogenesis occurred as evidenced by spermatozoa reappearing in the ejaculate exhibiting high levels of motility but significant levels of oxidative DNA damage as measured by a modified 8-OHdG assay protocol. These unique data indicate that even a moderate COVID-19 infection is capable of rapidly inducing a state of azoospermia that rapidly reverses as the infection wanes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.