ReviewSchizophrenia research. Cognition2022
Lifespan evolution of neurocognitive impairment in schizophrenia - A narrative review.
Review in Schizophrenia research. Cognition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07702526 (Effects of an Eye-Movement Intervention on Cognitive Impairment in Individuals Across Illness Stages of Schizophrenia), which is not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of an Eye-Movement Intervention on Cognitive Impairment in Individuals Across Illness Stages of Schizophrenia: Protocol for a Stratified Randomized, Active-Controlled, Assessor-Blinded Trial
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cognitive functioning in people with psychotic experiences: a systematic review and meta-analysis study.Molecular psychiatry · 2025Pooled it
- Biomarkers of neurodegeneration in schizophrenia: systematic review and meta-analysis.BMJ mental health · 2024Pooled it
- The experience of loneliness among people with psychosis: Qualitative meta-synthesis.PloS one · 2024Pooled it
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Moderating role of familial relationships in the efficacy of rTMS intervention on cognitive function in patients with schizophrenia.BMC psychiatry · 2025Trial
- A randomized controlled trial of Goal Management Training for executive functioning in schizophrenia spectrum disorders or psychosis risk syndromes.BMC psychiatry · 2022Trial
- Cross-linguistic benchmarking of NLP metrics for psychosis research.NPJ digital medicine · 2026Article
- Rethinking language, cognition and assessment in psychosis: How bilingualism challenges psychiatry and how natural language processing can help.Schizophrenia (Heidelberg, Germany) · 2026Review
- Back to the future: Linking early psychiatric symptoms to transdiagnostic cognitive functioning in at-risk youth from the adolescent brain cognitive development study.Journal of psychiatric research · 2026Article
- Cognition before and after psychosis onset: A naturalistic study of change, heterogeneity, and prognosis.Schizophrenia research. Cognition · 2025Review
- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- Pharmacologic and genetic evidence converge on mechanisms of psychotic illness.Translational psychiatry · 2025Article
- Association between white blood cell counts and the efficacy on cognitive function after rTMS intervention in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- [Long-term courses in schizophrenia : A review of current results and developments].Der Nervenarzt · 2025Review
- Why clinical neuropsychology matters in schizophrenia care.Frontiers in psychology · 2025Review
- Association of typical and atypical antipsychotics with mortality in older adults with schizophrenia: a 5-year multicenter prospective study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Observational
- Attention-mediated genetic influences on psychotic symptomatology in adolescence.Nature. Mental health · 2024Article
- Ten years ofSchizophrenia research. Cognition · 2024Article
- Intermittent Theta Burst Stimulation Combined with Cognitive Training to Improve Negative Symptoms and Cognitive Impairment in Schizophrenia: A Pilot Study.Brain sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment is a well-recognized key feature of schizophrenia. Here we review the evidence on (1) the onset and sensitive periods of change in cognitive impairment before and after the first psychotic episode, and (2) heterogeneity in neurocognitive presentations across cognitive domains between and within individuals. Overall, studies suggest that mild cognitive impairment in individuals who develop schizophrenia or related disorders is already present during early childhood. Cross-sectional studies further suggest increasing cognitive impairments from pre- to post-psychosis onset, with the greatest declines between adolescence, the prodrome, and the first psychotic episode and with some variability between domains. Longitudinal studies with more than 10 years of observation time are scarce but support mild cognitive declines after psychosis onset until late adulthood. Whether and how much this cognitive decline exceeds normal aging, proceeds further in older patients, and is specific to certain cognitive domains and subpopulations of patients remains to be investigated. Finally, studies show substantial heterogeneity in cognitive performance in schizophrenia and suggest a variety of impairment profiles. This review highlights a clear need for long-term studies that include a control group and individuals from adolescence to old age to better understand critical windows of cognitive change and their predictors. The available evidence stresses the importance of interventions that aim to counter cognitive decline during the prodromal years, as well as careful assessment of cognition in order to determine who will profit most from which cognitive training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.