Evidence map›Paper›PMID 35242572›Full record

ArticleMolecular genetics and metabolism reports2022

Familial lecithin-cholesterol acyltransferase deficiency: If so rare, why so frequent in the state of Piauí, northeastern Brazil?

Rafael Melo Santos de Serpa Brandão, Fábio Barros Britto, José Tiburcio do Monte Neto, Marcelo Cunha Lima, Semiramis Jamil Hadad do Monte, Antonio Vanildo de Sousa Lima, Ester Miranda Pereira, Higo José Neri da Silva, Deylane Menezes Teles E Oliveira, Antonio Gilberto Borges Coelho and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rafael Melo Santos de Serpa BrandãoLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Fábio Barros BrittoDepartment of Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 01. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
José Tiburcio do Monte NetoDepartment of General Practice - Nephrology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Marcelo Cunha LimaUniversitary Hospital (HU-UFPI/EBSERH), Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Semiramis Jamil Hadad do MonteLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Antonio Vanildo de Sousa LimaLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Ester Miranda PereiraLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Higo José Neri da SilvaMaster's Program in Science and Health, Federal University of Piauí, Teresina, Brazil, Centro de Ciências da Saúde, Avenida Frei Serafim n° 2280. Bairro Centro, Teresina, Piauí 64001-020, Brazil.
Deylane Menezes Teles E OliveiraGraduate Program in Biotechnology - RENORBIO, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Antonio Gilberto Borges CoelhoLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Adalberto Socorro da SilvaLaboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, Brazil, Campus Ministro Petrônio Portella - SG 16. Bairro Ininga, Teresina, Piauí 64049-550, Brazil.
Universidade Federal do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lecithin-cholesterol acyltransferase (LCAT), an enzyme that participates in lipoprotein metabolism, plays an important role in cholesterol homeostasis. Mutations in the

Indexed as

Chronic kidney diseaseFED, Fish-eye diseaseFLD, familial lecithin-cholesterol acyltransferase deficiencyGenetic relatednessHDL, high-density lipoproteinHigh-density lipoproteinsLCAT, lecithin-cholesterol acyltransferaseLecithin-cholesterol acyltransferaseMutationRare disease

Identifiers

PMID35242572
PMCPMC8856911
OpenAlexW4205509365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.