Evidence map›Paper›PMID 35242497›Full record

ArticleAnalytical cellular pathology (Amsterdam)2022

TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2.

Gang Yu, Wanjing Chen, Xianghua Li, Liang Yu, Yanyan Xu, Qiang Ruan, Yawei He, Yong Wang

Open access · goldAbstract read
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Implication of protein post translational modifications in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Targeting epigenetic regulators to overcome drug resistance in cancers.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gang YuDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0001-9217-1787
Wanjing ChenDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0002-6959-3591
Xianghua LiDepartment of Molecular Pathology, Hefei Da'an Medical Laboratory Co., Ltd., Hefei, 230012 Anhui, China.ORCID https://orcid.org/0000-0002-1968-9894
Liang YuDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0003-4547-8318
Yanyan XuDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0002-4890-3685
Qiang RuanDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0002-6138-4357
Yawei HeDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0002-4531-1086
Yong WangDepartment of General Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601 Anhui, China.ORCID https://orcid.org/0000-0003-2964-0514
Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between collagen type I alpha (COL1A) and chemoresistance has been verified in cancers. However, the specific role of COL1A2 in gastric cancer (GC) cell resistance to apatinib, a highly selective small-molecule inhibitor of vascular endothelial growth factor receptor 2, has not been investigated before. The purpose of this study was to explore the potential factors associated with COL1A2 regulation on GC cell apatinib resistance

Indexed as

Stomach NeoplasmsCell Line, TumorCollagen Type IE1A-Associated p300 ProteinHumansNuclear ProteinsPyridinesTwist-Related Protein 1Vascular Endothelial Growth Factor AapatinibCOL1A2 protein, humanCollagen Type ICollagen Type I, alpha2 SubunitE1A-Associated p300 ProteinEP300 protein, humanNuclear ProteinsPyridinesTWIST1 protein, humanTwist-Related Protein 1Vascular Endothelial Growth Factor A

Identifiers

PMID35242497
PMCPMC8888114
OpenAlexW4213057770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.