Evidence map›Paper›PMID 35242277›Full record

ArticleOxidative medicine and cellular longevity2022

Sphingosine 1-Phosphate-Upregulated COX-2/PGE

Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Mei-Hsiu Su, Chuen-Mao Yang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  7. Antioxidant Polyphenols fromAntioxidants (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chien-Chung YangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan 33302, Taiwan.ORCID https://orcid.org/0000-0003-2325-5017
Li-Der HsiaoDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Ya-Fang ShihDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Mei-Hsiu SuDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.
Chuen-Mao YangDepartment of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0002-3208-5438
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cardiac fibroblasts (HCFs) play key roles in normal physiological functions and pathological processes in the heart. Our recent study has found that, in HCFs, sphingosine 1-phosphate (S1P) can upregulate the expression of cyclooxygenase-2 (COX-2) leading to prostaglandin E

Indexed as

ApoptosisCell ProliferationCells, CulturedCell SurvivalCyclooxygenase 2DinoprostoneErbB ReceptorsFibroblastsHumansLysophospholipidsMAP Kinase Signaling SystemMatrix Metalloproteinase 9MyocardiumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSphingosineCyclooxygenase 2DinoprostoneEGFR protein, humanErbB ReceptorsLysophospholipidsMatrix Metalloproteinase 9MMP9 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTGS2 protein, humanSphingosinesphingosine 1-phosphateTranscription Factor AP-1

Identifiers

PMID35242277
PMCPMC8888119
OpenAlexW4214602315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.