Evidence map›Paper›PMID 35242266›Full record

ArticleApplied physics reviews2022

Study of sacrificial ink-assisted embedded printing for 3D perfusable channel creation for biomedical applications.

Bing Ren, Kaidong Song, Anil Reddy Sanikommu, Yejun Chai, Matthew A Longmire, Wenxuan Chai, Walter Lee Murfee, Yong Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physics reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. High-Speed Embedded Ink Writing of Anatomic-Size Organ Constructs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Bioprinting Technologies and Bioinks for Vascular Model Establishment.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bing RenDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Kaidong SongDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Anil Reddy SanikommuDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Yejun ChaiDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Matthew A LongmireDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Wenxuan ChaiDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.
Walter Lee MurfeeDepartment of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.
Yong HuangDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida 32611, USA.ORCID https://orcid.org/0000-0002-4691-7370
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For an engineered thick tissue construct to be alive and sustainable, it should be perfusable with respect to nutrients and oxygen. Embedded printing and then removing sacrificial inks in a cross-linkable yield-stress hydrogel matrix bath can serve as a valuable tool for fabricating perfusable tissue constructs. The objective of this study is to investigate the printability of sacrificial inks and the creation of perfusable channels in a cross-linkable yield-stress hydrogel matrix during embedded printing. Pluronic F-127, methylcellulose, and polyvinyl alcohol are selected as three representative sacrificial inks for their different physical and rheological properties. Their printability and removability performances have been evaluated during embedded printing in a gelatin microgel-based gelatin composite matrix bath, which is a cross-linkable yield-stress bath. The ink printability during embedded printing is different from that during printing in air due to the constraining effect of the matrix bath. Sacrificial inks with a shear-thinning property are capable of printing channels with a broad range of filaments by simply tuning the extrusion pressure. Bi-directional diffusion may happen between the sacrificial ink and matrix bath, which affects the sacrificial ink removal process and final channel diameter. As such, sacrificial inks with a low diffusion coefficient for gelatin precursor are desirable to minimize the diffusion from the gelatin precursor solution to minimize the post-printing channel diameter variation. For feasibility demonstration, a multi-channel perfusable alveolar mimic has been successfully designed, printed, and evaluated. The study results in the knowledge of the channel diameter controllability and sacrificial ink removability during embedded printing.

Identifiers

PMID35242266
PMCPMC8785228
OpenAlexW4206702313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.