Evidence map›Paper›PMID 35242243›Full record

ArticleDisease markers2022

Site-Specific Hypermethylation of SST 1stExon as a Biomarker for Predicting the Risk of Gastrointestinal Tract Cancers.

Xiantong Dai, Xin Sun, Ying Wu, Zhi Lv, Zhanwu Yu, Yuan Yuan, Liping Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiantong DaiTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.ORCID https://orcid.org/0000-0001-5451-6529
Xin SunTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.ORCID https://orcid.org/0000-0003-4381-025X
Ying WuTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.
Zhi LvTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.
Zhanwu YuDepartment of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Shenyang, Liaoning 110042, China.
Yuan YuanTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.ORCID https://orcid.org/0000-0002-7394-9036
Liping SunTumor Etiology and Screening Department of Cancer Institute, And Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang 110001, China.ORCID https://orcid.org/0000-0003-3637-0305
First Hospital of China Medical University · CNLiaoning Cancer Hospital & Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNA methylation is an important epigenetic modification in tumorigenesis, and similar epigenetic regulation mechanisms have been found in the gastrointestinal tract (GIT) cancers.

methodsDifferentially methylated regions (DMRs) of the

resultsIn GIT cancers, DMR-related CpG islands were mainly located in the 1stExon. The methylation status of the

conclusionsThe site-specific hypermethylation of the

Indexed as

DNA MethylationEpigenesis, GeneticRisk AssessmentBiomarkers, TumorCpG IslandsEsophageal NeoplasmsFemaleGastrointestinal NeoplasmsHumansMaleSequence Analysis, DNASomatostatinStomach NeoplasmsTranscriptomeBiomarkers, TumorSomatostatinSST protein, human

Identifiers

PMID35242243
PMCPMC8886765
OpenAlexW4211017069

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.